{"_buckets": {"deposit": "fd292049-9bfd-4742-9918-af28e947169c"}, "_deposit": {"created_by": 17, "id": "2002703", "owner": "17", "owners": [17], "owners_ext": {"displayname": "repository", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2002703"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02002703", "sets": ["501"]}, "author_link": [], "control_number": "2002703", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2023-04-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "1716", "bibliographicPageStart": "1709", "bibliographicVolumeNumber": "61", "bibliographic_titles": [{"bibliographic_title": "Rheumatology", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Objective: Anti-NOR90 antibodies are usually found in patients with SSc; however, their clinical relevance remains obscure. We developed an ELISA for measuring them to investigate the clinical features of patients with anti-NOR90 antibodies. Methods: Serum samples from 1252 patients with various conditions from Nagoya University Hospital and 244 patients with idiopathic interstitial pneumonia (IIP) from Tosei General Hospital were included. Anti-NOR90 antibodies were assayed by an ELISA using the recombinant protein produced by in vitro transcription/translation. Results: Five (0.4%) patients in the Nagoya University Hospital cohort had anti-NOR90 antibodies. One patient with diffuse cutaneous SSc, three with limited cutaneous SSc, and one with Raynaud’s disease were positive for anti-NOR90 antibodies. Anti-NOR90 antibodies were found more frequently in patients with systemic scleroderma-spectrum disorders (SSDs) than without SSDs (5/316 vs 0/936, P \u003c0.00101) and were found more frequently in patients with SSc than without SSc (4/249 vs 0/528, P \u003c0.0104) in the systemic autoimmune rheumatic diseases cohort. Three of the four anti-NOR90-positive SSc patients had interstitial lung disease (ILD), and two of those four had cancer. Three (1.2%) patients in the Tosei General Hospital cohort had anti-NOR90 antibodies. All three of the anti-NOR90-positive IIP patients had gastrointestinal tract involvement, and two of those three had cancer or skin lesions observed in SSc. Conclusions: Although anti-NOR90 antibodies are rarely found in clinics, our ELISA is useful for their detection. Further studies are needed to confirm the association of anti-NOR90 antibodies with ILD and cancer in SSc and IIP patients.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1093/rheumatology/keab575", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is a pre-copyedited, author-produced version of an article accepted for publication in [Rheumatology] following peer review. The version of record [Yuta Yamashita, Yasuhiko Yamano, Yoshinao Muro, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masashi Akiyama, Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia, Rheumatology, Volume 61, Issue 4, April 2022, Pages 1709–1716, https://doi.org/10.1093/rheumatology/keab575] is available online at: https://doi.org/10.1093/rheumatology/keab575.", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "1462-0324", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "embargoed access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_f1cf"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamashita, Yuta", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamano, Yasuhiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Muro, Yoshinao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ogawa-Momohara, Mariko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takeichi, Takuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kondoh, Yasuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Akiyama, Masashi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-04-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2023/3/31.", "file_order": 0, "filename": "RHE-21-1210_R1_Proof_hi.pdf", "filesize": [{"value": "908 KB"}], "format": "application/pdf", "future_date_message": "Download is available from 2023/3/31.", "is_thumbnail": false, "mimetype": "application/pdf", "size": 908000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2002703/files/RHE-21-1210_R1_Proof_hi.pdf"}, "version_id": "7b89c3d8-7973-4852-8b95-01de4d1e851b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "anti-NOR90 antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-nucleolar antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic interstitial pneumonia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interstitial lung disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "systemic autoimmune rheumatic disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "systemic sclerosis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/0002002703", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-05-11"}, "publish_date": "2022-05-11", "publish_status": "0", "recid": "2002703", "relation": {}, "relation_version_is_last": true, "title": ["Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia"], "weko_shared_id": -1}