| Item type |
itemtype_ver1(1) |
| 公開日 |
2022-05-11 |
| タイトル |
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|
タイトル |
Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia |
|
言語 |
en |
| 著者 |
Yamashita, Yuta
Yamano, Yasuhiko
Muro, Yoshinao
Ogawa-Momohara, Mariko
Takeichi, Takuya
Kondoh, Yasuhiro
Akiyama, Masashi
|
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
This is a pre-copyedited, author-produced version of an article accepted for publication in [Rheumatology] following peer review. The version of record [Yuta Yamashita, Yasuhiko Yamano, Yoshinao Muro, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masashi Akiyama, Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia, Rheumatology, Volume 61, Issue 4, April 2022, Pages 1709–1716, https://doi.org/10.1093/rheumatology/keab575] is available online at: https://doi.org/10.1093/rheumatology/keab575. |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
anti-NOR90 antibody |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
anti-nucleolar antibody |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
idiopathic interstitial pneumonia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
interstitial lung disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
systemic autoimmune rheumatic disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
systemic sclerosis |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objective: Anti-NOR90 antibodies are usually found in patients with SSc; however, their clinical relevance remains obscure. We developed an ELISA for measuring them to investigate the clinical features of patients with anti-NOR90 antibodies. Methods: Serum samples from 1252 patients with various conditions from Nagoya University Hospital and 244 patients with idiopathic interstitial pneumonia (IIP) from Tosei General Hospital were included. Anti-NOR90 antibodies were assayed by an ELISA using the recombinant protein produced by in vitro transcription/translation. Results: Five (0.4%) patients in the Nagoya University Hospital cohort had anti-NOR90 antibodies. One patient with diffuse cutaneous SSc, three with limited cutaneous SSc, and one with Raynaud’s disease were positive for anti-NOR90 antibodies. Anti-NOR90 antibodies were found more frequently in patients with systemic scleroderma-spectrum disorders (SSDs) than without SSDs (5/316 vs 0/936, P <0.00101) and were found more frequently in patients with SSc than without SSc (4/249 vs 0/528, P <0.0104) in the systemic autoimmune rheumatic diseases cohort. Three of the four anti-NOR90-positive SSc patients had interstitial lung disease (ILD), and two of those four had cancer. Three (1.2%) patients in the Tosei General Hospital cohort had anti-NOR90 antibodies. All three of the anti-NOR90-positive IIP patients had gastrointestinal tract involvement, and two of those three had cancer or skin lesions observed in SSc. Conclusions: Although anti-NOR90 antibodies are rarely found in clinics, our ELISA is useful for their detection. Further studies are needed to confirm the association of anti-NOR90 antibodies with ILD and cancer in SSc and IIP patients. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Oxford University Press |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1093/rheumatology/keab575 |
| 収録物識別子 |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1462-0324 |
| 書誌情報 |
en : Rheumatology
巻 61,
号 4,
p. 1709-1716,
発行日 2022-04
|
| ファイル公開日 |
|
|
日付 |
2023-04-01 |
|
日付タイプ |
Available |
RHE-21-1210_R1_Proof_hi.pdf (908 KB)
