{"_buckets": {"deposit": "7f4183e0-8b4f-489b-a8b9-5e7268c84215"}, "_deposit": {"created_by": 17, "id": "2003927", "owner": "17", "owners": [17], "owners_ext": {"displayname": "repository", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2003927"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02003927", "sets": ["501"]}, "author_link": [], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2023-09-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "1420", "bibliographicPageStart": "1411", "bibliographicVolumeNumber": "31", "bibliographic_titles": [{"bibliographic_title": "Experimental Dermatology", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Wrinkles and sagging are caused by various factors, such as ultraviolet rays; however, recent findings demonstrated that some individuals are genetically predisposed to these phenotypes of skin aging. The contribution of single nucleotide polymorphisms (SNPs) to the development of wrinkles and sagging has been demonstrated in genome-wide association studies (GWAS). However, these findings were mainly obtained from European and Chinese populations. Limited information is currently available on the involvement of SNPs in the development of wrinkles and sagging in a Japanese population. Therefore, we herein performed GWAS on wrinkles at the outer corners of the eyes and nasolabial folds in 1041 Japanese women. The results obtained revealed that 5 SNPs (19p13.2: rs2303098 (p = 3.39 × 10^−8), rs56391955 (p = 3.39 × 10^−8), rs67560822 (p = 3.50 × 10^−8), rs889126 (p = 3.78 × 10^−8), rs57490083 (p = 3.99 × 10^−8)) located within the COL5A3 gene associated with wrinkles at the outer corners of the eyes. Regarding nasolabial folds, 8q24.11 (rs4876369; p = 1.05 × 10^−7, rs6980503; p = 1.25 × 10^−7, rs61027543; p = 1.25 × 10^−7, rs16889363; p = 1.38 × 10^−7) was suggested to be associated with RAD21 gene expression. These SNPs have not been reported in other populations, and were first found in Japanese women population. These SNPs may be used as markers to examine the genetic predisposition of individuals to wrinkles and sagging.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1111/exd.14612", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "\"This is the peer reviewed version of the following article: [Okuno, R, Inoue, Y, Hasebe, Y, et al.. Genome-wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging. Exp Dermatol. 2022; 31: 1411-1420. doi: 10.1111/exd.14612], which has been published in final form at [https://doi.org/10.1111/exd.14612]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\"", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0906-6705", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "embargoed access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_f1cf"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okuno, Ryosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inoue, Yu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hasebe, Yuichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Igarashi, Toshio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawagishi‐Hotta, Mika", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamada, Takaaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hasegawa, Seiji", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-09-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2023/8/31.", "file_order": 0, "filename": "article.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "Download is available from 2023/8/31.", "is_thumbnail": false, "mimetype": "application/pdf", "size": 1100000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2003927/files/article.pdf"}, "version_id": "4c7cd570-c4ac-4511-ad66-f27bbc9cd158"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genome‐wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genome‐wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/0002003927", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-10-14"}, "publish_date": "2022-10-14", "publish_status": "0", "recid": "2003927", "relation": {}, "relation_version_is_last": true, "title": ["Genome‐wide association studies in Japanese women identified genetic loci associated with wrinkles and sagging"], "weko_shared_id": -1}