| Item type |
itemtype_ver1(1) |
| 公開日 |
2022-11-22 |
| タイトル |
|
|
タイトル |
The effects of ustekinumab on small intestinal lesions and stenotic lesions |
|
言語 |
en |
| 著者 |
Wada, Hirotaka
Murate, Kentaro
Nakamura, Masanao
Furukawa, Kazuhiro
Kakushima, Naomi
Yamamura, Takeshi
Maeda, Keiko
Sawada, Tsunaki
Ishikawa, Eri
Ishikawa, Takuya
Ohno, Eizaburo
Honda, Takashi
Kawashima, Hiroki
Nakayama, Goro
Hattori, Norifumi
Umeda, Shinichi
Ishigami, Masatoshi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Crohn’s disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
small bowel endoscopy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
stenotic small intestine lesion |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
total colonoscopy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ustekinumab |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Crohn’s disease patients suffer from symptoms originating from small bowel lesions, including strictures. As many of these patients also have a potential risk of surgery, it is important to consider various therapeutic strategies for small bowel lesions. We retrospectively analyzed the therapeutic effects of ustekinumab, interleukin-12 and -23 blocker, for small intestinal lesions and intestinal stenosis in order to contribute to the optimal management of Crohn’s disease. Patients who underwent total colonoscopy or small bowel endoscopy before and after the introduction of ustekinumab were enrolled in this study. The colonoscopy findings were evaluated by the simple endoscopic score for Crohn’s disease, and small bowel endoscopy findings were evaluated using the modified simple endoscopic score for Crohn’s disease. Endoscopic scores were compared before and after the introduction of ustekinumab and between the responders and non-responders to ustekinumab. Responders were defined as those whose Crohn’s disease activity index score at 24 weeks fell below 150 points, or those whose score decreased by more than 100 points from the pre-induction level. A total of 50 patients were enrolled in the study, and the number of responders was 35. Pre-induction simple endoscopic scores were lower for responders, but no significant difference was observed in the modified simple endoscopic scores. The total decrease in the endoscopic score was significantly higher in the responders for both the small and large intestine. Use of ustekinumab as a first-line treatment for patients with small bowel lesions or stricture-prone lesions may be a new treatment consideration in the future. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.84.4.825 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/844.html |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 84,
号 4,
p. 825-838,
発行日 2022-11
|
13_Wada.pdf (3.2 MB)
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