{"_buckets": {"deposit": "dddeb63d-4d90-4349-b9ea-7d79f42100cd"}, "_deposit": {"created_by": 17, "id": "2004238", "owner": "17", "owners": [17], "owners_ext": {"displayname": "repository", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2004238"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02004238", "sets": ["501"]}, "author_link": [], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2023-09-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "1294", "bibliographicPageStart": "1286", "bibliographicVolumeNumber": "28", "bibliographic_titles": [{"bibliographic_title": "Journal of Infection and Chemotherapy", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Introduction: We aimed to clarify the genetic background and molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae (K. pneumoniae) at three geographically separated university hospitals in Japan. Methods: From January 2014 to December 2016, 118 ESBL-producing K. pneumoniae (EPKP) strains that were detected and stored at three university hospitals were collected. Molecular epidemiological analysis was performed using enterobacterial repetitive intergenic consensus (ERIC)-polymerase chain reaction (PCR) and multi-locus sequence typing (MLST). The ESBL type was determined using the PCR-sequence method. The presence of plasmid-mediated fluoroquinolone resistance (PMQR) genes was analyzed by PCR. We compared the relationships between PMQR gene possession/quinolone resistance-determining region (QRDR) mutation and levofloxacin (LVFX)/ciprofloxacin (CPFX) susceptibility. Results: The detection rate of EPKP was 4.8% (144/2987 patients). MLST analysis revealed 62 distinct sequence types (STs). The distribution of STs was diverse, and only some EPKP strains had the same STs. ERIC-PCR showed discriminatory power similar to that of MLST. The major ESBL genotypes were CTX-M-15-, CTX-M-14-, and SHV-types, which were detected in 47, 30, and 27 strains, respectively. Ninety-one out of 118 strains had PMQR genes and 14 out of 65 strains which were not susceptible to CPFX had QRDR mutations, and the accumulation of PMQR genes and QRDR mutations tended to lead to higher minimum inhibitory concentrations (MICs) of LVFX. Conclusions: At three geographically separated university hospitals in Japan, the epidemiology of EPKP was quite diverse, and no epidemic strains were found, whereas CTX-M-14 and CTX-M-15 were predominant.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jiac.2022.05.013", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "1341321X", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "embargoed access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_f1cf"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Oka, Keisuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tetsuka, Nobuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Morioka, Hiroshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Iguchi, Mitsutaka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazumitsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hayashi, Kengo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yanagiya, Takako", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Morokuma, Yuiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Watari, Tomohisa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kiyosuke, Makiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yagi, Tetsuya", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-09-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2023/8/31.", "file_order": 0, "filename": "JICHE-D-22-00239_R1.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "Download is available from 2023/8/31.", "is_thumbnail": false, "mimetype": "application/pdf", "size": 1100000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2004238/files/JICHE-D-22-00239_R1.pdf"}, "version_id": "d6a1504a-c190-4636-ac09-a15bd6874173"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genetic and epidemiological analysis of ESBL-producing Klebsiella pneumoniae in three Japanese university hospitals", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genetic and epidemiological analysis of ESBL-producing Klebsiella pneumoniae in three Japanese university hospitals", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/0002004238", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-11-30"}, "publish_date": "2022-11-30", "publish_status": "0", "recid": "2004238", "relation": {}, "relation_version_is_last": true, "title": ["Genetic and epidemiological analysis of ESBL-producing Klebsiella pneumoniae in three Japanese university hospitals"], "weko_shared_id": -1}