Item type |
itemtype_ver1(1) |
公開日 |
2023-07-28 |
タイトル |
|
|
タイトル |
Discovery of New Cytotoxic Aplaminone Derivatives from the Sea Hare Aplysia kurodai and Elucidation of Their Accumulation from Local Sea Algae through the Food Chain |
|
言語 |
en |
著者 |
Hioki, Yusuke
Sato, Tatsuya
Iwao, Toyoki
Ikuma, Junya
Kawamura, Atsushi
Ohyoshi, Takayuki
Tsunematsu, Yuta
Kita, Masaki
|
アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利 |
|
|
言語 |
en |
|
権利情報 |
"This is the peer reviewed version of the following article: [Hioki, Y., Sato, T., Iwao, T., Ikuma, J., Kawamura, A., Ohyoshi, T., Tsunematsu, Y., Kita, M., Eur. J. Org. Chem. 2023, 26, e202300084.], which has been published in final form at [https://doi.org/10.1002/ejoc.202300084]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The shell-less herbivorous marine mollusk (sea hare) Aplysia kurodai is known to contain a variety of bioactive substances. While these compounds have been thought to originate from sea algae or their associated microbes, most of their origin and acquisition pathways are still unclear. Six new cytotoxic aplaminone derivatives, bromodopamine-terpenoid hybrid molecules, were isolated from A. kurodai. Among them, isoaplaminone had a reverse prenyl group at the C15 aliphatic chain, which is a rare structural feature from the viewpoint of terpenoid biosynthesis. Investigation for chemical components in A. kurodai and the sea algae collected at several different locations revealed that two major aplaminones were contained in the Laurencia complex species at specific sites. Our chemical and ecological studies provide new insights into the origin of marine alkaloid toxins and their dynamism through the food chain. |
|
言語 |
en |
出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
言語 |
|
|
言語 |
eng |
資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/ejoc.202300084 |
収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1434-193X |
書誌情報 |
en : European Journal of Organic Chemistry
巻 26,
号 12,
p. e202300084,
発行日 2023-03-21
|
ファイル公開日 |
|
|
日付 |
2024-03-21 |
|
日付タイプ |
Available |