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Diseases categorized as autoinflammatory keratinization diseases (AiKDs), and their pathologies and treatments
https://doi.org/10.18999/nagjms.86.1.1
https://doi.org/10.18999/nagjms.86.1.12af33dbd-ec25-46aa-b362-2622acbeaf27
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
01_Akiyama.pdf (6.3 MB)
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| Item type | itemtype_ver1(1) | |||||||
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| 公開日 | 2024-02-27 | |||||||
| タイトル | ||||||||
| タイトル | Diseases categorized as autoinflammatory keratinization diseases (AiKDs), and their pathologies and treatments | |||||||
| 言語 | en | |||||||
| 著者 |
Akiyama, Masashi
× Akiyama, Masashi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | hidradenitis suppurativa | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | keratosis lichenoides chronica | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | pityriasis rubra pilaris | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | porokeratosis | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | pustular psoriasis | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Whole-exome and whole-genome sequencing have become widespread in approximately the last 15 years, and the predisposing factors and pathomechanisms of inflammatory keratinization diseases, which have been unknown for a long time, have gradually been revealed. Hence, various inflammatory keratinization diseases are recognized to cause innate immunity hyperactivation. Therefore, we have been advocating for the clinical entity, “autoinflammatory keratinization diseases (AiKDs)” since 2017. AiKDs are inflammatory keratinization diseases caused by autoinflammatory-related pathomechanisms in the skin. The aberrant activation of innate immunity and the resultant autoinflammation in the epidermis and the superficial dermis in AiKDs cause hyperkeratosis in the epidermis. Our initially proposed concept of AiKDs included generalized pustular psoriasis and related conditions, pityriasis rubra pilaris type V, and familial keratosis lichenoides chronica. Since then, the number of diseases known to be AiKDs has increased as previously unknown disease-causing factors and pathogenetic mechanisms of inflammatory keratinization diseases have been clarified one by one. To date, porokeratosis, hidradenitis suppurative, keratosis linearis with ichthyosis congenita and sclerosing keratoderma (KLICK) syndrome, and AiKDs associated with epidermal growth factor receptor (EGFR) deficiency or with hepatitis and autism have been recognized as AiKDs. The concept of AiKDs is considered extremely useful in our precise understanding of the pathogeneses behind inflammatory keratinization diseases and our appropriate treatment method selection. The number of AiKDs is expected to grow with the clarification of the pathomechanisms of further inflammatory keratinization diseases. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| ID登録 | ||||||||
| ID登録 | 10.18999/nagjms.86.1.1 | |||||||
| ID登録タイプ | JaLC | |||||||
| 関連情報 | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/861.html | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0027-7622 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2186-3326 | |||||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 86, 号 1, p. 1-15, 発行日 2024-02 |
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