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Nature of storage iron turnover
https://doi.org/10.18999/nagjms.86.3.361
https://doi.org/10.18999/nagjms.86.3.36136c907cd-c5de-49ee-8427-c4839be767df
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
02_Saito.pdf (1.1 MB)
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| Item type | itemtype_ver1(1) | |||||||
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| 公開日 | 2024-08-29 | |||||||
| タイトル | ||||||||
| タイトル | Nature of storage iron turnover | |||||||
| 言語 | en | |||||||
| 著者 |
Saito, Hiroshi
× Saito, Hiroshi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | quantitation of ferritin and hemosiderin iron | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | computer-assisted serum ferritin kinetics | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | radioiron reflux from storage iron | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | storage iron turnover rat | |||||||
| キーワード | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | iron-attracting potential of iron-storing cells | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Despite recent advance in the study of the nature of storage iron turnover, a comprehensive analysis remains lacking. This study aimed to clarify the nature of storage iron turnover. Ferritin-hemosiderin iron transformation rate and the standard normal storage iron turnover rate were utilized in this study to describe the mechanism of iron absorption in relation to ferritin and hemosiderin iron turnover. The synchronization of radioiron uptake peaks by bone marrow and liver indicates that the distribution of radioiron is proportional to the pre-existing iron levels in organs at 24 h after radioiron injection. Moreover, the synchronization indicates the independence of iron mass from red cell precursors in acquiring plasma iron. Thus, the erythron does not dominate the radioiron uptake process. The inverse correlation between transformation rate and the amount of pre-existing iron storage implies that the intra-storage iron turnover is active in iron deficiency, but inactive in iron overload. The decreased ferritin/hemosiderin iron ratio in chronic hepatitis C (CHC) with normal iron storage suggests a trend of iron transformation from ferritin into hemosiderin. The correlation between the pretreatment iron storage and the speed of rebound in CHC implies that the vacant iron-storing rooms in iron-removed cells have a potential to increase iron absorption. This study presents new insights into the turnover of stored iron to enhance our understanding of iron metabolism in various hematologic disorders. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| ID登録 | ||||||||
| ID登録 | 10.18999/nagjms.86.3.361 | |||||||
| ID登録タイプ | JaLC | |||||||
| 関連情報 | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | URI | |||||||
| 関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/863.html | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0027-7622 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2186-3326 | |||||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 86, 号 3, p. 361-369, 発行日 2024-08 |
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