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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(4)

Neuroinflammation in motor neuron disease

https://doi.org/10.18999/nagjms.77.4.537
https://doi.org/10.18999/nagjms.77.4.537
ea00770a-8809-44d1-9581-ce01c51f3467
名前 / ファイル ライセンス アクション
01_Komine.pdf 01_Komine.pdf (832.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-11-24
タイトル
タイトル Neuroinflammation in motor neuron disease
著者 Komine, Okiru

× Komine, Okiru

WEKO 60935

Komine, Okiru

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Yamanaka, Koji

× Yamanaka, Koji

WEKO 60936

Yamanaka, Koji

Search repository
キーワード
主題Scheme Other
主題 neuroinflammation
キーワード
主題Scheme Other
主題 glia
キーワード
主題Scheme Other
主題 ALS
キーワード
主題Scheme Other
主題 neurodegenerative disease
抄録
内容記述 Increasing evidence suggests that the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) is not restricted to the neurons but attributed to the abnormal interactions of neurons and surrounding glial and lymphoid cells. These findings led to the concept of non-cell autonomous neurodegeneration. Neuroinflammation, which is mediated by activated glial cells and infiltrated lymphocytes and accompanied by the subsequent production of proinflammatory cytokines and neurotoxic or neuroprotective molecules, is characteristic to the pathology in ALS and is a key component for non-cell autonomous neurodegeneration. This review covers the involvement of microglia and astrocytes in the ALS mouse models and human ALS, and it also covers the deregulated pathways in motor neurons, which are involved in initiating the disease. Based on the cell-type specific pathomechanisms of motor neuron disease, targeting of neuroinflammation could lead to future therapeutic strategies for ALS and could be potentially applied to other neurodegenerative diseases.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.4.537
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 4, p. 537-549, 発行日 2015-11
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/774.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/23219
識別子タイプ HDL
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