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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(4)

Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload

https://doi.org/10.18999/nagjms.77.4.571
https://doi.org/10.18999/nagjms.77.4.571
4b4c3e4d-9004-4527-9067-9a92a93f30c8
名前 / ファイル ライセンス アクション
13_Saito.pdf 13_Saito.pdf (385.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-11-24
タイトル
タイトル Transformation rate between ferritin and hemosiderin assayed by serum ferritin kinetics in patients with normal iron stores and iron overload
著者 Saito, Hiroshi

× Saito, Hiroshi

WEKO 60949

Saito, Hiroshi

Search repository
Hayashi, Hisao

× Hayashi, Hisao

WEKO 60950

Hayashi, Hisao

Search repository
キーワード
主題Scheme Other
主題 transformation among iron stores
キーワード
主題Scheme Other
主題 ferritin and hemosiderin
キーワード
主題Scheme Other
主題 serum ferritin kinetics
キーワード
主題Scheme Other
主題 hereditary hemochromatosis
キーワード
主題Scheme Other
主題 chronic hepatitis C
抄録
内容記述 Ferritin iron, hemosiderin iron, total iron stores and transformation rate were determined by serum ferritin kinetics. The transformation rate between ferritin and hemosiderin is motivated by the potential difference between them. The transformer determines transformation rate according to the potential difference in iron mobilization and deposition. The correlations between transformation rate and iron stores were studied in 11 patients with chronic hepatitis C (CHC), 1 patent with treated iron deficiency anemia (TIDA), 9 patients with hereditary hemochromatosis (HH) and 4 patients with transfusion-dependent anemia (TD). The power regression curve of approximation showed an inverse correlation between transformation rate and ferritin iron, hemosiderin iron in part and total iron stores in HH. Such an inverse correlation between transformation rate and iron stores implies that the larger the amount of iron stores, the smaller the transformation of iron stores. On the other hand, a minimal inverse correlation between transformation rate and ferritin iron and no correlation between transformation rate and hemosiderin iron or total iron stores in CHC indicate the derangement of storage iron metabolism in the cells with CHC. Radio-iron fixation on the iron storing tissue in iron overload was larger than that in normal subjects by ferrokinetics. This is consistent with the inverse correlation between transformation rate and total iron stores in HH. The characteristics of iron turnover between ferritin and hemosiderin were disclosed from the correlation between transformation rate and ferritin iron, hemosiderin iron or total iron stores.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.4.571
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 4, p. 571-583, 発行日 2015-11
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/774.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/23222
識別子タイプ HDL
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