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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(4)

Elevated serum interleukin-23 levels in ankylosing spondylitis patients and the relationship with disease activity

https://doi.org/10.18999/nagjms.77.4.621
https://doi.org/10.18999/nagjms.77.4.621
ec8a62bb-1341-4ed2-83ff-4b2cf6011431
名前 / ファイル ライセンス アクション
17_Mahir.pdf 17_Mahir.pdf (165.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-11-24
タイトル
タイトル Elevated serum interleukin-23 levels in ankylosing spondylitis patients and the relationship with disease activity
著者 Ugur, Mahir

× Ugur, Mahir

WEKO 60977

Ugur, Mahir

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Baygutalp, Nurcan Kilic

× Baygutalp, Nurcan Kilic

WEKO 60978

Baygutalp, Nurcan Kilic

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Melikoglu, Meltem Alkan

× Melikoglu, Meltem Alkan

WEKO 60979

Melikoglu, Meltem Alkan

Search repository
Baygutalp, Fatih

× Baygutalp, Fatih

WEKO 60980

Baygutalp, Fatih

Search repository
Altas, Elif Umay

× Altas, Elif Umay

WEKO 60981

Altas, Elif Umay

Search repository
Seferoglu, Buminhan

× Seferoglu, Buminhan

WEKO 60982

Seferoglu, Buminhan

Search repository
キーワード
主題Scheme Other
主題 ankylosing spondylitis
キーワード
主題Scheme Other
主題 disease activity
キーワード
主題Scheme Other
主題 interleukin-23
抄録
内容記述 This study was aimed to evaluate the relationship between serum interleukin-23 (IL-23) levels and ankylosing spondylitis (AS).Twenty male patients diagnosed with ankylosing spondylitis according to the 1984 modified New York criteria for AS and twenty male healthy controls were included in this study. The demographic characteristics, clinical and laboratory findings of the patients were recorded. Serum IL-23 levels, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured in both the AS and control groups. The Bath ankylosing spondylitis disease activity ındex (BASDAI), the Bath ankylosing spondylitis functional index (BASFI), and the Bath ankylosing spondylitis metrology index (BASMI) were evaluated as disease activity parameters. The AS patients were divided into two subgroups as active and inactive in respect of CRP, ESR levels and BASDAI scores. The mean serum IL-23 levels of the AS and control groups were 334.45±176.54 pg/ml and 166.49±177.50 pg/ml respectively, and there was a significant difference between the groups. Correlation analysis of serum IL-23 levels with clinical and laboratory parameters showed that there were positive correlations between serum IL-23 levels and the BASDAI, BASFI scores in total, active and inactive patients and the BASMI scores in total and inactive patients and negative correlations between serum IL-23 levels and ESR in inactive patients. It was shown that altered serum IL-23 levels were related to AS disease activity. Further studies in large patient series are necessary to investigate the role of IL-23 protein in etiopathogenesis of AS.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.4.621
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 4, p. 621-627, 発行日 2015-11
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/774.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/23226
識別子タイプ HDL
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