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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 78(2)

ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men

https://doi.org/10.18999/nagjms.78.2.183
https://doi.org/10.18999/nagjms.78.2.183
aef8e229-41ec-46ee-800b-35a7a3a98af1
名前 / ファイル ライセンス アクション
16_GuangYin.pdf 16_GuangYin.pdf (248.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-05-23
タイトル
タイトル ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men
著者 Yin, Guang

× Yin, Guang

WEKO 65648

Yin, Guang

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Naito, Mariko

× Naito, Mariko

WEKO 65649

Naito, Mariko

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Wakai, Kenji

× Wakai, Kenji

WEKO 65650

Wakai, Kenji

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Morita, Emi

× Morita, Emi

WEKO 65651

Morita, Emi

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Kawai, Sayo

× Kawai, Sayo

WEKO 65652

Kawai, Sayo

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Hamajima, Nobuyuki

× Hamajima, Nobuyuki

WEKO 65653

Hamajima, Nobuyuki

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Suzuki, Sadao

× Suzuki, Sadao

WEKO 65654

Suzuki, Sadao

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Kita, Yoshikuni

× Kita, Yoshikuni

WEKO 65655

Kita, Yoshikuni

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Takezaki, Toshiro

× Takezaki, Toshiro

WEKO 65656

Takezaki, Toshiro

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Tanaka, Keitaro

× Tanaka, Keitaro

WEKO 65657

Tanaka, Keitaro

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Morita, Makiko

× Morita, Makiko

WEKO 65658

Morita, Makiko

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Uemura, Hirokazu

× Uemura, Hirokazu

WEKO 65659

Uemura, Hirokazu

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Ozaki, Etsuko

× Ozaki, Etsuko

WEKO 65660

Ozaki, Etsuko

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Hosono, Satoyo

× Hosono, Satoyo

WEKO 65661

Hosono, Satoyo

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Mikami, Haruo

× Mikami, Haruo

WEKO 65662

Mikami, Haruo

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Kubo, Michiaki

× Kubo, Michiaki

WEKO 65663

Kubo, Michiaki

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Tanaka, Hideo

× Tanaka, Hideo

WEKO 65664

Tanaka, Hideo

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キーワード
主題Scheme Other
主題 ADH1B and ALDH2 polymorphisms
キーワード
主題Scheme Other
主題 type 2 diabetes
キーワード
主題Scheme Other
主題 fasting blood glucose
キーワード
主題Scheme Other
主題 alcohol consumption
抄録
内容記述 Associations between alcohol consumption and type 2 diabetes risk are inconsistent in epidemiologic
studies. This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting blood
glucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levels
in Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35–69 years.
The subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across six
areas of Japan. The ADH1B and ALDH2 polymorphisms were genotyped by Invader Assays. The ALDH2
Glu504Lys genotypes were associated with different levels of fasting blood glucose in men (P = 0.04).
Mean fasting glucose level was positively associated with alcohol consumption in men with the ALDH2
504 Lys allele (Ptrend = 0.02), but not in men with the ALDH2 504Glu/Glu genotype (Ptrend = 0.45), resulting
in no statistically significant interaction (P = 0.38). Alcohol consumption was associated with elevated
fasting blood glucose levels compared with non-consumers in men (Ptrend = 0.002). The ADH1B Arg48His
polymorphism was not associated with FBG levels overall or after stratification for alcohol consumption.
These findings suggest that the ALDH2 polymorphism is associated with different levels of fasting blood
glucose through alcohol consumption in Japanese men. The interaction of ALDH2 polymorphisms in the
association between alcohol consumption and fasting blood glucose warrants further investigation.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.78.2.183
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 78, 号 2, p. 183-193, 発行日 2016-05
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/782.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/24196
識別子タイプ HDL
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