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This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting blood\nglucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levels\nin Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35–69 years.\nThe subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across six\nareas of Japan. The ADH1B and ALDH2 polymorphisms were genotyped by Invader Assays. The ALDH2\nGlu504Lys genotypes were associated with different levels of fasting blood glucose in men (P = 0.04).\nMean fasting glucose level was positively associated with alcohol consumption in men with the ALDH2\n504 Lys allele (Ptrend = 0.02), but not in men with the ALDH2 504Glu/Glu genotype (Ptrend = 0.45), resulting\nin no statistically significant interaction (P = 0.38). Alcohol consumption was associated with elevated\nfasting blood glucose levels compared with non-consumers in men (Ptrend = 0.002). The ADH1B Arg48His\npolymorphism was not associated with FBG levels overall or after stratification for alcohol consumption.\nThese findings suggest that the ALDH2 polymorphism is associated with different levels of fasting blood\nglucose through alcohol consumption in Japanese men. 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ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men
https://doi.org/10.18999/nagjms.78.2.183
https://doi.org/10.18999/nagjms.78.2.183aef8e229-41ec-46ee-800b-35a7a3a98af1
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-05-23 | |||||
タイトル | ||||||
タイトル | ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men | |||||
著者 |
Yin, Guang
× Yin, Guang× Naito, Mariko× Wakai, Kenji× Morita, Emi× Kawai, Sayo× Hamajima, Nobuyuki× Suzuki, Sadao× Kita, Yoshikuni× Takezaki, Toshiro× Tanaka, Keitaro× Morita, Makiko× Uemura, Hirokazu× Ozaki, Etsuko× Hosono, Satoyo× Mikami, Haruo× Kubo, Michiaki× Tanaka, Hideo |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | ADH1B and ALDH2 polymorphisms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | type 2 diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fasting blood glucose | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alcohol consumption | |||||
抄録 | ||||||
内容記述 | Associations between alcohol consumption and type 2 diabetes risk are inconsistent in epidemiologic studies. This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting blood glucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levels in Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35–69 years. The subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across six areas of Japan. The ADH1B and ALDH2 polymorphisms were genotyped by Invader Assays. The ALDH2 Glu504Lys genotypes were associated with different levels of fasting blood glucose in men (P = 0.04). Mean fasting glucose level was positively associated with alcohol consumption in men with the ALDH2 504 Lys allele (Ptrend = 0.02), but not in men with the ALDH2 504Glu/Glu genotype (Ptrend = 0.45), resulting in no statistically significant interaction (P = 0.38). Alcohol consumption was associated with elevated fasting blood glucose levels compared with non-consumers in men (Ptrend = 0.002). The ADH1B Arg48His polymorphism was not associated with FBG levels overall or after stratification for alcohol consumption. These findings suggest that the ALDH2 polymorphism is associated with different levels of fasting blood glucose through alcohol consumption in Japanese men. The interaction of ALDH2 polymorphisms in the association between alcohol consumption and fasting blood glucose warrants further investigation. |
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内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.78.2.183 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 78, 号 2, p. 183-193, 発行日 2016-05 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/782.html | |||||
識別子タイプ | URI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/24196 | |||||
識別子タイプ | HDL |