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Growth rate of chemotherapy-naïve lung metastasis from colorectal cancer could be a predictor of early relapse after lung resection
http://hdl.handle.net/2237/24918
http://hdl.handle.net/2237/2491865bfefba-faa7-4868-89c6-880de89177b7
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Fig2_Kawaguchi.pdf (28.5 kB)
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Fig1_Kawaguchi.pdf (40.5 kB)
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article_Kawaguchi.pdf (169.4 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-09-29 | |||||
| タイトル | ||||||
| タイトル | Growth rate of chemotherapy-naïve lung metastasis from colorectal cancer could be a predictor of early relapse after lung resection | |||||
| 言語 | en | |||||
| 著者 |
Kawaguchi, Koji
× Kawaguchi, Koji× Uehara, Keisuke× Nakayama, Goro× Fukui, Takayuki× Fukumoto, Koichi× Nakamura, Shota× Yokoi, Kohei |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | The final publication is available at Springer via http://doi.org/10.1007/s10147-015-0889-1 | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Colorectal cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lung resection | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Metastasectomy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tumor doubling time | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Growth rate | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The aim of this study was to elucidate a potential risk factor for early relapse after pulmonary metastasectomy of colorectal cancer and to propose an optimal treatment strategy for lung metastasis with an aggressive nature. Methods: Seventy patients who underwent pulmonary metastasectomy for diachronically measurable pulmonary lesions were retrospectively analyzed. We calculated the tumor doubling time (TDT) as the growth rate of lung metastasis and divided the study population into two groups: Rapid (TDT ≤ 100 days) and Slow (TDT > 100 days). Results: The patients consisted of 47 males and 23 females, with a mean age of 63 years. Forty-two patients had a relapse after pulmonary metastasectomy with a median follow-up duration of 24 months. There was a significant difference in relapse-free survival between the Rapid and Slow groups (p = 0.047). Using a multivariate analysis, no preoperative chemotherapy and a high level of serum carcinoembryonic antigen were proven to be significant risk factors for relapse after metastasectomy. Meanwhile, multivariate analyses among 37 patients without preoperative chemotherapy indicated that TDT was the sole significant factor for relapse-free survival. In addition, eight of nine patients with relapse within 12 months were placed into the Rapid group. Conclusions: Although this was a preliminary study with a small number of patients, it suggested that lung metastases demonstrating a TDT of 100 days or less have a high risk of early relapse after metastasectomy. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | First Online: 18 August 2015 | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10147-015-0889-1 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1341-9625 | |||||
| 書誌情報 |
en : International Journal of Clinical Oncology 巻 21, 号 2, p. 329-334, 発行日 2016-04 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1007/s10147-015-0889-1 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/24918 | |||||
| 識別子タイプ | HDL | |||||
