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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 78(4)

Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging

https://doi.org/10.18999/nagjms.78.4.455
https://doi.org/10.18999/nagjms.78.4.455
c79f9ba4-458b-4015-a7f8-aca496eced44
名前 / ファイル ライセンス アクション
21_Senda.pdf 21_Senda.pdf (17.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-11-29
タイトル
タイトル Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging
著者 Senda, Joe

× Senda, Joe

WEKO 67653

Senda, Joe

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Watanabe, Hirohisa

× Watanabe, Hirohisa

WEKO 67654

Watanabe, Hirohisa

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Endo, Kuniyuki

× Endo, Kuniyuki

WEKO 67655

Endo, Kuniyuki

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Yasui, Keizo

× Yasui, Keizo

WEKO 67656

Yasui, Keizo

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Hawsegawa, Yasuhiro

× Hawsegawa, Yasuhiro

WEKO 67657

Hawsegawa, Yasuhiro

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Yoneyama, Noritaka

× Yoneyama, Noritaka

WEKO 67658

Yoneyama, Noritaka

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Tsuboi, Takashi

× Tsuboi, Takashi

WEKO 67659

Tsuboi, Takashi

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Hara, Kazuhiro

× Hara, Kazuhiro

WEKO 67660

Hara, Kazuhiro

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Ito, Mizuki

× Ito, Mizuki

WEKO 67661

Ito, Mizuki

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Atsuta, Naoki

× Atsuta, Naoki

WEKO 67662

Atsuta, Naoki

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Epifanio, Bagarinao Jr.

× Epifanio, Bagarinao Jr.

WEKO 67663

Epifanio, Bagarinao Jr.

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Katsuno, Masahisa

× Katsuno, Masahisa

WEKO 67664

Katsuno, Masahisa

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Naganawa, Shinji

× Naganawa, Shinji

WEKO 67665

Naganawa, Shinji

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Sobue, Gen

× Sobue, Gen

WEKO 67666

Sobue, Gen

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キーワード
主題Scheme Other
主題 multiple sclerosis (MS)
キーワード
主題Scheme Other
主題 fingolimod
キーワード
主題Scheme Other
主題 voxel based morphometry (VBM)
キーワード
主題Scheme Other
主題 diffusion tensor
キーワード
主題Scheme Other
主題 imaging (DTI)
キーワード
主題Scheme Other
主題 fluid-attenuated inversion recovery (FLAIR) high-intensity signals
抄録
内容記述 Voxel-based analysis (VBA) of diffusion tensor images (DTI) and voxel-based morphometry (VBM) in patients with multiple sclerosis (MS) can sensitively detect occult tissue damage that underlies pathological changes in the brain. In the present study, both at the start of fingolimod and post-four months clinical remission, we assessed four patients with MS who were evaluated with VBA of DTI, VBM, and fluid-attenuated inversion recovery (FLAIR). DTI images for all four patients showed widespread areas of increased mean diffusivity (MD) and decreased fractional anisotropy (FA) that were beyond the highintensity signal areas across images. After four months of continuous fingolimod therapy, DTI abnormalities progressed; in particular, MD was significantly increased, while brain volume and high-intensity signals were unchanged. These findings suggest that VBA of DTI (e.g., MD) may help assess MS demyelination as neuroinflammatory conditions, even though clinical manifestations of MS appear to be in complete remission during fingolimod.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.78.4.455
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 78, 号 4, p. 455-463, 発行日 2016-11
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/784.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/25126
識別子タイプ HDL
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