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Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging
https://doi.org/10.18999/nagjms.78.4.455
https://doi.org/10.18999/nagjms.78.4.455c79f9ba4-458b-4015-a7f8-aca496eced44
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
21_Senda.pdf (17.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-11-29 | |||||
| タイトル | ||||||
| タイトル | Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging | |||||
| 言語 | en | |||||
| 著者 |
Senda, Joe
× Senda, Joe× Watanabe, Hirohisa× Endo, Kuniyuki× Yasui, Keizo× Hawsegawa, Yasuhiro× Yoneyama, Noritaka× Tsuboi, Takashi× Hara, Kazuhiro× Ito, Mizuki× Atsuta, Naoki× Epifanio, Bagarinao Jr.× Katsuno, Masahisa× Naganawa, Shinji× Sobue, Gen |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | multiple sclerosis (MS) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fingolimod | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | voxel based morphometry (VBM) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diffusion tensor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | imaging (DTI) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fluid-attenuated inversion recovery (FLAIR) high-intensity signals | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Voxel-based analysis (VBA) of diffusion tensor images (DTI) and voxel-based morphometry (VBM) in patients with multiple sclerosis (MS) can sensitively detect occult tissue damage that underlies pathological changes in the brain. In the present study, both at the start of fingolimod and post-four months clinical remission, we assessed four patients with MS who were evaluated with VBA of DTI, VBM, and fluid-attenuated inversion recovery (FLAIR). DTI images for all four patients showed widespread areas of increased mean diffusivity (MD) and decreased fractional anisotropy (FA) that were beyond the highintensity signal areas across images. After four months of continuous fingolimod therapy, DTI abnormalities progressed; in particular, MD was significantly increased, while brain volume and high-intensity signals were unchanged. These findings suggest that VBA of DTI (e.g., MD) may help assess MS demyelination as neuroinflammatory conditions, even though clinical manifestations of MS appear to be in complete remission during fingolimod. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.78.4.455 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/784.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 78, 号 4, p. 455-463, 発行日 2016-11 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25126 | |||||
| 識別子タイプ | HDL | |||||
