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Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer
http://hdl.handle.net/2237/25152
http://hdl.handle.net/2237/25152f45b4195-548c-4bbc-a1e1-4d9cd9b1bc24
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PRMT5-MK_2016_IJO.pdf ファイル公開：2017/02/01 (537.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-12-05 | |||||
| タイトル | ||||||
| タイトル | Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer | |||||
| 言語 | en | |||||
| 著者 |
Kanda, Mitsuro
× Kanda, Mitsuro× Shimizu, Dai× Fujii, Tsutomu× Tanaka, Haruyoshi× Shibata, Masahiro× Iwata, Naoki× Hayashi, Masamichi× Kobayashi, Daisuke× Tanaka, Chie× Yamada, Suguru× Nakayama, Goro× Sugimoto, Hiroyuki× Koike, Masahiko× Fujiwara, Michitaka× Kodera, Yasuhiro |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Identification of novel gastric cancer (GC)-related molecules is necessary to improve management of patients with GC in both diagnostic and therapeutic aspects. The aim of the present study was to determine whether protein arginine methyltransferase 5 (PRMT5) acts as an oncogene in the progression of GC and whether it serves as a novel diagnostic marker and therapeutic target. We conducted global expression profiling of GC cell lines and RNA interference experiments to evaluate the effect of PRMT5 expression on the phenotype of GC cells. We analysed tissues of 179 patients with GC to assess the association of PRMT5 mRNA levels with clinicopathological factors. Differential expression of PRMT5 mRNA by GC cell lines correlated positively with the levels of GEMIN2, STAT3 and TGFB3. PRMT5 knockdown reduced the proliferation, invasion and migration of a GC cell line. PRMT5 mRNA levels were significantly higher in GC tissues than the corresponding adjacent normal tissues and were independent of tumour depth, differentiation and lymph node metastasis. High PRMT5 expression was an independent risk factor of positive peritoneal lavage cytology (odds ratio 3.90, P=0.003) and decreased survival. PRMT5 enhances the malignant phenotype of GC cell lines and its expression in gastric tissues may serve as a biomarker for patient stratification and a potential target of therapy. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Spandidos Publications | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.3892/ijo.2016.3584 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1019-6439 | |||||
| 書誌情報 |
en : International Journal of Oncology 巻 49, 号 3, p. 1195-1202, 発行日 2016-09 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.3892/ijo.2016.3584 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25152 | |||||
| 識別子タイプ | HDL | |||||
