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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer

http://hdl.handle.net/2237/25152
http://hdl.handle.net/2237/25152
f45b4195-548c-4bbc-a1e1-4d9cd9b1bc24
名前 / ファイル ライセンス アクション
PRMT5-MK_2016_IJO.pdf PRMT5-MK_2016_IJO.pdf ファイル公開:2017/02/01 (537.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-12-05
タイトル
タイトル Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer
言語 en
著者 Kanda, Mitsuro

× Kanda, Mitsuro

WEKO 67807

en Kanda, Mitsuro

Search repository
Shimizu, Dai

× Shimizu, Dai

WEKO 67808

en Shimizu, Dai

Search repository
Fujii, Tsutomu

× Fujii, Tsutomu

WEKO 67809

en Fujii, Tsutomu

Search repository
Tanaka, Haruyoshi

× Tanaka, Haruyoshi

WEKO 67810

en Tanaka, Haruyoshi

Search repository
Shibata, Masahiro

× Shibata, Masahiro

WEKO 67811

en Shibata, Masahiro

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Iwata, Naoki

× Iwata, Naoki

WEKO 67812

en Iwata, Naoki

Search repository
Hayashi, Masamichi

× Hayashi, Masamichi

WEKO 67813

en Hayashi, Masamichi

Search repository
Kobayashi, Daisuke

× Kobayashi, Daisuke

WEKO 67814

en Kobayashi, Daisuke

Search repository
Tanaka, Chie

× Tanaka, Chie

WEKO 67815

en Tanaka, Chie

Search repository
Yamada, Suguru

× Yamada, Suguru

WEKO 67816

en Yamada, Suguru

Search repository
Nakayama, Goro

× Nakayama, Goro

WEKO 67817

en Nakayama, Goro

Search repository
Sugimoto, Hiroyuki

× Sugimoto, Hiroyuki

WEKO 67818

en Sugimoto, Hiroyuki

Search repository
Koike, Masahiko

× Koike, Masahiko

WEKO 67819

en Koike, Masahiko

Search repository
Fujiwara, Michitaka

× Fujiwara, Michitaka

WEKO 67820

en Fujiwara, Michitaka

Search repository
Kodera, Yasuhiro

× Kodera, Yasuhiro

WEKO 67821

en Kodera, Yasuhiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 Identification of novel gastric cancer (GC)-related molecules is necessary to improve management of patients with GC in both diagnostic and therapeutic aspects. The aim of the present study was to determine whether protein arginine methyltransferase 5 (PRMT5) acts as an oncogene in the progression of GC and whether it serves as a novel diagnostic marker and therapeutic target. We conducted global expression profiling of GC cell lines and RNA interference experiments to evaluate the effect of PRMT5 expression on the phenotype of GC cells. We analysed tissues of 179 patients with GC to assess the association of PRMT5 mRNA levels with clinicopathological factors. Differential expression of PRMT5 mRNA by GC cell lines correlated positively with the levels of GEMIN2, STAT3 and TGFB3. PRMT5 knockdown reduced the proliferation, invasion and migration of a GC cell line. PRMT5 mRNA levels were significantly higher in GC tissues than the corresponding adjacent normal tissues and were independent of tumour depth, differentiation and lymph node metastasis. High PRMT5 expression was an independent risk factor of positive peritoneal lavage cytology (odds ratio 3.90, P=0.003) and decreased survival. PRMT5 enhances the malignant phenotype of GC cell lines and its expression in gastric tissues may serve as a biomarker for patient stratification and a potential target of therapy.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Spandidos Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3892/ijo.2016.3584
ISSN
収録物識別子タイプ PISSN
収録物識別子 1019-6439
書誌情報 en : International Journal of Oncology

巻 49, 号 3, p. 1195-1202, 発行日 2016-09
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.3892/ijo.2016.3584
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25152
識別子タイプ HDL
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