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S100G expression and function in fibroblasts on colitis induction
http://hdl.handle.net/2237/25157
http://hdl.handle.net/2237/251571f03081c-9eea-4070-b3b0-bc4fe745966e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
S100GpaperDepo.pdf ファイル公開：2017/10/01 (936.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-12-07 | |||||
| タイトル | ||||||
| タイトル | S100G expression and function in fibroblasts on colitis induction | |||||
| 言語 | en | |||||
| 著者 |
Ishiguro, Kazuhiro
× Ishiguro, Kazuhiro× Watanabe, Osamu× Nakamura, Masanao× Yamamura, Takeshi× Ando, Takafumi× Goto, Hidemi× Hirooka, Yoshiki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Interleukin-10 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Inflammatory bowel diseases | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | S100G | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fibroblasts | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Monocyte chemotactic protein-1 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Supplementation with interleukin (IL)-10, an important anti-inflammatory cytokine, has shown disappointing efficacy for inflammatory bowel diseases (IBD). IL-10 may down-regulate the expression of other anti-inflammatory mediators following colitis induction. We used a colitis model characterized by hapten-protein visualization, which indicates the site of hapten-protein formation after colitis induction for histological and gene expression analyses. Under IL-10 deficiency, following colitis induction inflammatory changes were reduced, and S100G expression was elevated. S100G was expressed in fibroblasts, and S100G expression was down-regulated by IL-10. S100G suppressed the production of monocyte chemotactic protein-1 (MCP-1) through the inhibition of NF-κB activation. Therefore, S100G, also known as Calbindin-D9k, may be an important anti-inflammatory mediator in fibroblasts following colitis induction, and down-regulation of S100G expression might be one reason for the insufficient performance of IL-10 supplementation. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.intimp.2016.07.017 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1567-5769 | |||||
| 書誌情報 |
en : International Immunopharmacology 巻 39, p. 92-96, 発行日 2016-10 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1016/j.intimp.2016.07.017 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25157 | |||||
| 識別子タイプ | HDL | |||||
