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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats

http://hdl.handle.net/2237/25159
http://hdl.handle.net/2237/25159
1f693915-f2b2-41b0-9326-f98fc7db9f72
名前 / ファイル ライセンス アクション
Manuscript_20161107.pdf Manuscript_20161107.pdf ファイル公開:2017/09/01 (9.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-12-07
タイトル
タイトル Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats
言語 en
著者 Muramatsu, Yukako

× Muramatsu, Yukako

WEKO 67862

en Muramatsu, Yukako

Search repository
Ito, Mikako

× Ito, Mikako

WEKO 67863

en Ito, Mikako

Search repository
Oshima, Takahiro

× Oshima, Takahiro

WEKO 67864

en Oshima, Takahiro

Search repository
Kojima, Seiji

× Kojima, Seiji

WEKO 67865

en Kojima, Seiji

Search repository
Ohno, Kinji

× Ohno, Kinji

WEKO 67866

en Ohno, Kinji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Muramatsu, Y., Ito, M., Oshima, T., Kojima, S. and Ohno, K. (2016), Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats. Pediatr Pulmonol., 51: 928–935], which has been published in final form at [http://doi.org/10.1002/ppul.23386]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Bronchopulmonary dysplasia (BPD) is characterized by developmental arrest of the alveolar tissue. Oxidative stress is causally associated with development of BPD. The effects of hydrogen have been reported in a wide range of disease models and human diseases especially caused by oxidative stress. We made a rat model of BPD by injecting lipopolysaccharide (LPS) into the amniotic fluid at E16.5. The mother started drinking hydrogen-rich water from E9.5 and also while feeding milk. Hydrogen normalized LPS-induced abnormal enlargement of alveoli at P7 and P14. LPS increased staining for nitrotyrosine and 8-OHdG of the lungs, and hydrogen attenuated the staining. At P1, LPS treatment decreased expressions of genes for FGFR4, VEGFR2, and HO-1 in the lungs, and hydrogen increased expressions of these genes. In contrast, LPS treatment and hydrogen treatment had no essential effect on the expression of SOD1. Inflammatory marker proteins of TNFα and IL-6 were increased by LPS treatment, and hydrogen suppressed them. Treatment of A549 human lung adenocarcinoma epithelial cells with 10% hydrogen gas for 24 hr decreased production of reactive oxygen species in both LPS-treated and untreated cells. Lack of any known adverse effects of hydrogen makes hydrogen a promising therapeutic modality for BPD.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/ppul.23386
ISSN
収録物識別子タイプ PISSN
収録物識別子 8755-6863
書誌情報 en : Pediatric Pulmonology

巻 51, 号 9, p. 928-935, 発行日 2016-09
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/ppul.23386
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25159
識別子タイプ HDL
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