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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis

http://hdl.handle.net/2237/25161
http://hdl.handle.net/2237/25161
0fb1ab8f-d738-4112-9472-ebd90127ae81
名前 / ファイル ライセンス アクション
Accepted_version_of_the_manuscript.pdf Accepted_version_of_the_manuscript.pdf ファイル公開:2017/05/01 (874.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-12-08
タイトル
タイトル FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis
言語 en
著者 Masuda, Akio

× Masuda, Akio

WEKO 67874

en Masuda, Akio

Search repository
Takeda, Jun-ichi

× Takeda, Jun-ichi

WEKO 67875

en Takeda, Jun-ichi

Search repository
Ohno, Kinji

× Ohno, Kinji

WEKO 67876

en Ohno, Kinji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Masuda, A., Takeda, J.-i. and Ohno, K. (2016), FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis. WIREs RNA, 7: 330–340], which has been published in final form at [http://doi.org/10.1002/wrna.1338]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Fused in sarcoma (FUS) is an RNA-binding protein that is causally associated with oncogenesis and neurodegeneration. Recently, the role of FUS in neurodegeneration has been extensively studied, because mutations in FUS are associated with amyotrophic lateral sclerosis (ALS), and the FUS protein has been identified as a major component of intracellular inclusions in neurodegenerative disorders including ALS and frontotemporal lobar degeneration. FUS is a key molecule in transcriptional regulation and RNA processing including processes such as pre-messenger RNA (mRNA) splicing and polyadenylation. Interaction of FUS with various components of the transcription machinery, spliceosome, and the 3′-end processing machinery has been identified. Furthermore, recent advances in high-throughput transcriptomic profiling approaches have enabled us to determine the mechanisms of FUS-dependent RNA processing networks at a cellular level. These analyses have revealed that depletion of FUS in neuronal cells affects alternative splicing and alternative polyadenylation of thousands of mRNAs. Gene ontology analysis has suggested that FUS-modulated genes are implicated in neuronal functions and development. CLIP-seq of FUS has shown that FUS is frequently clustered around these alternative sites of nascent RNA. ChIP-seq of RNA polymerase II (RNAP II) has demonstrated that an interaction between FUS and nascent RNA downregulates local transcriptional activity of RNAP II, which is critically involved in RNA processing. Both alternative splicing and alternative polyadenylation are fundamental processes by which cells expand their transcriptomic diversity, and are particularly essential in the nervous system. Dependence of transcriptomic diversity on FUS makes the nervous system vulnerable to neurodegeneration, when FUS is functionally compromised. WIREs RNA 2016, 7:330–340. doi: 10.1002/wrna.1338
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/wrna.1338
ISSN
収録物識別子タイプ PISSN
収録物識別子 1757-7004
書誌情報 en : Wiley Interdisciplinary Reviews: RNA

巻 7, 号 3, p. 330-340, 発行日 2016-05
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/wrna.1338
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25161
識別子タイプ HDL
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