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Haspin has Multiple Functions in the Plant Cell Division Regulatory Network
http://hdl.handle.net/2237/25194
http://hdl.handle.net/2237/2519490898f1c-46ed-4c55-8e84-af3c8cbb4b9d
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-12-14 | |||||
タイトル | ||||||
タイトル | Haspin has Multiple Functions in the Plant Cell Division Regulatory Network | |||||
言語 | en | |||||
著者 |
Kozgunova, Elena
× Kozgunova, Elena× Suzuki, Takamasa× Ito, Masaki× Higashiyama, Tetsuya× Kurihara, Daisuke |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in [Plant & Cell Physiology] following peer review. The version of record [Plant & Cell Physiology. v.57, n.4, 2016, p.848-861] is available online at: http://doi.org/10.1093/pcp/pcw030. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aurora3 kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BY-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chromosome alignment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokinesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Haspin | |||||
抄録 | ||||||
内容記述 | Progression of cell division is controlled by various mitotic kinases. In animal cells, phosphorylation of histone H3 at Thr3 by the kinase Haspin (haploid germ cell-specific nuclear protein kinase) promotes centromeric Aurora B localization to regulate chromosome segregation. However, less is known about the function of Haspin in regulatory networks in plant cells. Here, we show that inhibition of Haspin with 5-iodotubercidin (5-ITu) in Bright Yellow-2 (BY-2) cells delayed chromosome alignment. Haspin inhibition also prevented the centromeric localization of Aurora3 kinase (AUR3) and disrupted its function. This suggested that Haspin plays a role in the specific positioning of AUR3 on chromosomes in plant cells, a function conserved in animals. The results also indicated that Haspin and AUR3 are involved in the same pathway, which regulates chromosome alignment during prometaphase/metaphase. Remarkably, Haspin inhibition by 5-ITu also led to a severe cytokinesis defect, resulting in binuclear cells with a partially formed cell plate. The 5-ITu treatment did not affect microtubules, AUR1/2 or the NACK–PQR pathway; however, it did alter the distribution of actin filaments on the cell plate. Together, these results suggested that Haspin has several functions in regulating cell division in plant cells: in the localization of AUR3 on centromeres and in regulating late cell plate expansion during cytokinesis. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Oxford University Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/pcp/pcw030 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0032-0781 | |||||
書誌情報 |
en : Plant & Cell Physiology 巻 57, 号 4, p. 848-861, 発行日 2016-02-12 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1093/pcp/pcw030 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25194 | |||||
識別子タイプ | HDL |