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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis

http://hdl.handle.net/2237/25205
http://hdl.handle.net/2237/25205
3a078e30-13ab-4e44-82eb-67f1f8495b9b
名前 / ファイル ライセンス アクション
Final-20160626-HK-Manuscript-Main.pdf Final-20160626-HK-Manuscript-Main.pdf ファイル公開:2017/09/01 (317.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-12-15
タイトル
タイトル A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis
言語 en
著者 Kawase, Haruya

× Kawase, Haruya

WEKO 68032

en Kawase, Haruya

Search repository
Bando, K. Yasuko

× Bando, K. Yasuko

WEKO 68033

en Bando, K. Yasuko

Search repository
Nishimura, Kazuyuki

× Nishimura, Kazuyuki

WEKO 68034

en Nishimura, Kazuyuki

Search repository
Aoyama, Morihiko

× Aoyama, Morihiko

WEKO 68035

en Aoyama, Morihiko

Search repository
Monji, Akio

× Monji, Akio

WEKO 68036

en Monji, Akio

Search repository
Murohara, Toyoaki

× Murohara, Toyoaki

WEKO 68037

en Murohara, Toyoaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
抄録
内容記述 Background: To address the impact of antidiabetic drugs on cardiovascular safety is a matter of clinical concern. Preclinical studies revealed that various protective effects of dipeptidyl peptidase-4 inhibitor (DPP4i) on cardiovascular disease; however, its impact of on hypertension remains controversial. Methods and results: Teneligliptin (TEN; 10 mg/kg/day/p.o.) ameliorates hypertension and cardiac remodeling by normalizing a rise of angiotensin-II (AngII) that specifically observed in spontaneously hypertensive rats (SHR). TEN had no effects on vasculature and concentrations of the DPP4-related vasoactive peptides (bradykinin, neuropeptide Y, and atrial natriuretic peptide). The primary action of TEN on BP lowering was due to restoring the AngII-induced manifestation of congestive heart failure observed in SHR. Sodium-proton pump exchanger type 1 (NHE-1) is a regulator of intracellular acidity (pHi) and implicated pathophysiological role in cardiac remodeling occurred in diseased myocardium. Cardiac NHE-1 expression level was increased in SHR and this was restored in TEN-treated SHR. AngII directly augmented cardiac NHE-1 expression and its activity that contributed to hypertrophic response. TEN attenuated the AngII-induced cardiac hypertrophy with decline in pHi via suppression of NHE-1. Loss of NHE-1 activity by specific inhibitor or RNA silencing promoted intracellular acidification and consistently attenuated the AngII-mediated cardiac hypertrophy. Conclusion: The present study revealed the protective actions of TEN on hypertension and comorbid cardiac remodeling via AngII/NHE-1 axis and the novel pathophysiological roles of intracellular acidification via NHE-1 in cardiac hypertrophy.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.yjmcc.2016.06.066
ISSN
収録物識別子タイプ PISSN
収録物識別子 0022-2828
書誌情報 en : Journal of Molecular and Cellular Cardiology

巻 98, p. 37-47, 発行日 2016-09
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1016/j.yjmcc.2016.06.066
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25205
識別子タイプ HDL
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