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  1. F100 環境医学研究所
  2. F100a 雑誌掲載論文
  3. 学術雑誌

Partial IK1 blockade destabilizes spiral wave rotation center without inducing wave breakup and facilitates termination of reentrant arrhythmias in ventricles

http://hdl.handle.net/2237/25335
6c3657ca-05c3-4fa7-b99c-e9e8c60e1922
名前 / ファイル ライセンス アクション
AJP_H_00228_2016_R1.pdf AJP_H_00228_2016_R1.pdf ファイル公開:2017/09/01 (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-11
タイトル
タイトル Partial IK1 blockade destabilizes spiral wave rotation center without inducing wave breakup and facilitates termination of reentrant arrhythmias in ventricles
著者 Kushiyama, Yasunori

× Kushiyama, Yasunori

WEKO 68614

Kushiyama, Yasunori

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Honjo, Haruo

× Honjo, Haruo

WEKO 68615

Honjo, Haruo

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Niwa, Ryoko

× Niwa, Ryoko

WEKO 68616

Niwa, Ryoko

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Takanari, Hiroki

× Takanari, Hiroki

WEKO 68617

Takanari, Hiroki

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Yamazaki, Masatoshi

× Yamazaki, Masatoshi

WEKO 68618

Yamazaki, Masatoshi

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Takemoto, Yoshio

× Takemoto, Yoshio

WEKO 68619

Takemoto, Yoshio

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Sakuma, Ichiro

× Sakuma, Ichiro

WEKO 68620

Sakuma, Ichiro

Search repository
Kodama, Itsuo

× Kodama, Itsuo

WEKO 68621

Kodama, Itsuo

Search repository
Kamiya, Kaichiro

× Kamiya, Kaichiro

WEKO 68622

Kamiya, Kaichiro

Search repository
権利
権利情報 (c)American Physiological Society
抄録
内容記述 It has been reported that blockade of the inward rectifier K+ current (IK1) facilitates termination of ventricular fibrillation. We hypothesized that partial IK1 blockade destabilizes spiral wave (SW) re-entry, leading to its termination. Optical action potential (AP) signals were recorded from left ventricles of Langendorff-perfused rabbit hearts with endocardial cryoablation. The dynamics of SW re-entry were analyzed during ventricular tachycardia (VT), induced by cross-field stimulation. Intercellular electrical coupling in the myocardial tissue was evaluated by the space constant. In separate experiments, AP recordings were made using the microelectrode technique from right ventricular papillary muscles of rabbit hearts. Ba2+ (10–50 μM) caused a dose-dependent prolongation of VT cycle length and facilitated termination of VT in perfused hearts. Baseline VT was maintained by a stable rotor, where an SW rotated around an I-shaped functional block line (FBL). Ba2+ at 10 μM prolonged I-shaped FBL and phase-singularity trajectory, whereas Ba2+ at 50 μM transformed the SW rotation dynamics from a stable linear pattern to unstable circular/cycloidal meandering. The SW destabilization was not accompanied by SW breakup. Under constant pacing, Ba2+ caused a dose-dependent prolongation of APs, and Ba2+ at 50 μM decreased conduction velocity. In papillary muscles, Ba2+ at 50 μM depolarized the resting membrane potential. The space constant was increased by 50 μM Ba2+. Partial IK1 blockade destabilizes SW rotation dynamics through a combination of prolongation of the wave length, reduction of excitability, and enhancement of electrotonic interactions, which facilitates termination of ventricular tachyarrhythmias.
内容記述タイプ Abstract
出版者
出版者 American Physiological Society
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0363-6135
書誌情報 American Journal of Physiology - Heart and Circulatory Physiology

巻 311, 号 3, p. H750-H758, 発行日 2016-09-01
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1152/ajpheart.00228.2016
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25335
識別子タイプ HDL
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