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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki)

http://hdl.handle.net/2237/25397
http://hdl.handle.net/2237/25397
e5c9445f-2c58-4121-ab10-fc9f1cffe8f8
名前 / ファイル ライセンス アクション
J_Biol_Chem_2016-Irie-13891-904.pdf J_Biol_Chem_2016-Irie-13891-904.pdf ファイル公開:2017/06/24 (4.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-17
タイトル
タイトル MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki)
言語 en
著者 Irie, Koichiro

× Irie, Koichiro

WEKO 68731

en Irie, Koichiro

Search repository
Tsujimura, Keita

× Tsujimura, Keita

WEKO 68732

en Tsujimura, Keita

Search repository
Nakashima, Hideyuki

× Nakashima, Hideyuki

WEKO 68733

en Nakashima, Hideyuki

Search repository
Nakashima, Kinichi

× Nakashima, Kinichi

WEKO 68734

en Nakashima, Kinichi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This research was originally published in The Journal of Biological Chemistry. Koichiro Irie, Keita Tsujimura, Hideyuki Nakashima, and Kinichi Nakashima<br/>. MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki). The Journal of Biological Chemistry. 2016; 291:pp.13891-pp.13904. © the American Society for Biochemistry and Molecular Biology.
キーワード
主題Scheme Other
主題 dendrite
キーワード
主題Scheme Other
主題 microRNA (miRNA)
キーワード
主題Scheme Other
主題 neurite outgrowth
キーワード
主題Scheme Other
主題 neurodevelopment
キーワード
主題Scheme Other
主題 RNA binding protein
キーワード
主題Scheme Other
主題 schizophrenia
抄録
内容記述 Proper dendritic elaboration of neurons is critical for the formation of functional circuits during brain development. Defects in dendrite morphogenesis are associated with neuropsychiatric disorders, and microRNAs are emerging as regulators of aspects of neuronal maturation such as axonal and dendritic growth, spine formation, and synaptogenesis. Here, we show that miR-214 plays a pivotal role in the regulation of dendritic development. Overexpression of miR-214 increased dendrite size and complexity, whereas blocking of endogenous miR-214-3p, a mature form of miR-214, inhibited dendritic morphogenesis. We also found that miR-214-3p targets quaking (Qki), which is implicated in psychiatric diseases such as schizophrenia, through conserved target sites located in the 3′-untranslated region of Qki mRNA, thereby down-regulating Qki protein levels. Overexpression and knockdown of Qki impaired and enhanced dendritic formation, respectively. Moreover, overexpression of Qki abolished the dendritic growth induced by miR-214 overexpression. Taken together, our findings reveal a crucial role for the miR-214-Qki pathway in the regulation of neuronal dendritic development.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 American Society for Biochemistry and Molecular Biology
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1074/jbc.M115.705749
ISSN
収録物識別子タイプ PISSN
収録物識別子 0021-9258
書誌情報 en : The Journal of Biological Chemistry

巻 291, p. 13891-13904, 発行日 2016-06-24
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.1074/jbc.M115.705749
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25397
識別子タイプ HDL
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