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MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki)
http://hdl.handle.net/2237/25397
http://hdl.handle.net/2237/25397e5c9445f-2c58-4121-ab10-fc9f1cffe8f8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
J_Biol_Chem_2016-Irie-13891-904.pdf ファイル公開：2017/06/24 (4.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-17 | |||||
| タイトル | ||||||
| タイトル | MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki) | |||||
| 言語 | en | |||||
| 著者 |
Irie, Koichiro
× Irie, Koichiro× Tsujimura, Keita× Nakashima, Hideyuki× Nakashima, Kinichi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This research was originally published in The Journal of Biological Chemistry. Koichiro Irie, Keita Tsujimura, Hideyuki Nakashima, and Kinichi Nakashima<br/>. MicroRNA-214 Promotes Dendritic Development by Targeting the Schizophrenia-associated Gene Quaking (Qki). The Journal of Biological Chemistry. 2016; 291:pp.13891-pp.13904. © the American Society for Biochemistry and Molecular Biology. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dendrite | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microRNA (miRNA) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neurite outgrowth | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neurodevelopment | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RNA binding protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | schizophrenia | |||||
| 抄録 | ||||||
| 内容記述 | Proper dendritic elaboration of neurons is critical for the formation of functional circuits during brain development. Defects in dendrite morphogenesis are associated with neuropsychiatric disorders, and microRNAs are emerging as regulators of aspects of neuronal maturation such as axonal and dendritic growth, spine formation, and synaptogenesis. Here, we show that miR-214 plays a pivotal role in the regulation of dendritic development. Overexpression of miR-214 increased dendrite size and complexity, whereas blocking of endogenous miR-214-3p, a mature form of miR-214, inhibited dendritic morphogenesis. We also found that miR-214-3p targets quaking (Qki), which is implicated in psychiatric diseases such as schizophrenia, through conserved target sites located in the 3′-untranslated region of Qki mRNA, thereby down-regulating Qki protein levels. Overexpression and knockdown of Qki impaired and enhanced dendritic formation, respectively. Moreover, overexpression of Qki abolished the dendritic growth induced by miR-214 overexpression. Taken together, our findings reveal a crucial role for the miR-214-Qki pathway in the regulation of neuronal dendritic development. | |||||
| 言語 | en | |||||
| 内容記述タイプ | Abstract | |||||
| 出版者 | ||||||
| 言語 | en | |||||
| 出版者 | American Society for Biochemistry and Molecular Biology | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1074/jbc.M115.705749 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0021-9258 | |||||
| 書誌情報 |
en : The Journal of Biological Chemistry 巻 291, p. 13891-13904, 発行日 2016-06-24 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1074/jbc.M115.705749 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25397 | |||||
| 識別子タイプ | HDL | |||||
