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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model

http://hdl.handle.net/2237/25422
http://hdl.handle.net/2237/25422
7bce16a3-9bc0-4928-b8db-b9b4f86f889c
名前 / ファイル ライセンス アクション
journal_pone_0142786.pdf journal_pone_0142786.pdf (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-18
タイトル
タイトル Zonisamide Enhances Neurite Elongation of Primary Motor Neurons and Facilitates Peripheral Nerve Regeneration In Vitro and in a Mouse Model
言語 en
著者 Yagi, Hideki

× Yagi, Hideki

WEKO 68888

en Yagi, Hideki

Search repository
Ohkawara, Bisei

× Ohkawara, Bisei

WEKO 68889

en Ohkawara, Bisei

Search repository
Nakashima, Hiroaki

× Nakashima, Hiroaki

WEKO 68890

en Nakashima, Hiroaki

Search repository
Ito, Kenyu

× Ito, Kenyu

WEKO 68891

en Ito, Kenyu

Search repository
Tsushima, Mikito

× Tsushima, Mikito

WEKO 68892

en Tsushima, Mikito

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Ishii, Hisao

× Ishii, Hisao

WEKO 68893

en Ishii, Hisao

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Noto, Kimitoshi

× Noto, Kimitoshi

WEKO 68894

en Noto, Kimitoshi

Search repository
Ohta, Kyotaro

× Ohta, Kyotaro

WEKO 68895

en Ohta, Kyotaro

Search repository
Masuda, Akio

× Masuda, Akio

WEKO 68896

en Masuda, Akio

Search repository
Imagama, Shiro

× Imagama, Shiro

WEKO 68897

en Imagama, Shiro

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 68898

en Ishiguro, Naoki

Search repository
Ohno, Kinji

× Ohno, Kinji

WEKO 68899

en Ohno, Kinji

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2015 Yagi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
抄録
内容記述 No clinically applicable drug is currently available to enhance neurite elongation after nerve injury. To identify a clinically applicable drug, we screened pre-approved drugs for neurite elongation in the motor neuron-like NSC34 cells. We found that zonisamide, an anti-epileptic and anti-Parkinson’s disease drug, promoted neurite elongation in cultured primary motor neurons and NSC34 cells in a concentration-dependent manner. The neurite-scratch assay revealed that zonisamide enhanced neurite regeneration. Zonisamide was also protective against oxidative stress-induced cell death of primary motor neurons. Zonisamide induced mRNA expression of nerve growth factors (BDNF, NGF, and neurotrophin-4/5), and their receptors (tropomyosin receptor kinase A and B). In a mouse model of sciatic nerve autograft, intragastric administration of zonisamide for 1 week increased the size of axons distal to the transected site 3.9-fold. Zonisamide also improved the sciatic function index, a marker for motor function of hindlimbs after sciatic nerve autograft, from 6 weeks after surgery. At 8 weeks after surgery, zonisamide was protective against denervation-induced muscle degeneration in tibialis anterior, and increased gene expression of Chrne, Colq, and Rapsn, which are specifically expressed at the neuromuscular junction. We propose that zonisamide is a potential therapeutic agent for peripheral nerve injuries as well as for neuropathies due to other etiologies.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 Correction: http://hdl.handle.net/2237/25424
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 PLOS
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0142786
ISSN
収録物識別子タイプ EISSN
収録物識別子 1932-6203
書誌情報 en : PLOS ONE

巻 10, 号 11, p. e0142786-e0142786, 発行日 2015-11
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1371/journal.pone.0142786
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25422
識別子タイプ HDL
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