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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

http://hdl.handle.net/2237/25530
e971f8f4-8bfd-4f4f-be0a-4b55d143c568
名前 / ファイル ライセンス アクション
art_A10_1186_F1742-2094-9-53.pdf art_A10_1186_F1742-2094-9-53.pdf (396.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-26
タイトル
タイトル The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury
著者 Tauchi, Ryoji

× Tauchi, Ryoji

WEKO 69156

Tauchi, Ryoji

Search repository
Imagama, Shiro

× Imagama, Shiro

WEKO 69157

Imagama, Shiro

Search repository
Natori, Takamitsu

× Natori, Takamitsu

WEKO 69158

Natori, Takamitsu

Search repository
Ohgomori, Tomohiro

× Ohgomori, Tomohiro

WEKO 69159

Ohgomori, Tomohiro

Search repository
Muramoto, Akio

× Muramoto, Akio

WEKO 69160

Muramoto, Akio

Search repository
Shinjo, Ryuichi

× Shinjo, Ryuichi

WEKO 69161

Shinjo, Ryuichi

Search repository
Matsuyama, Yukihiro

× Matsuyama, Yukihiro

WEKO 69162

Matsuyama, Yukihiro

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 69163

Ishiguro, Naoki

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 69164

Kadomatsu, Kenji

Search repository
権利
権利情報 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
キーワード
主題Scheme Other
主題 ADAMTS-4
キーワード
主題Scheme Other
主題 Spinal cord injury
キーワード
主題Scheme Other
主題 Extracellular matrix
キーワード
主題Scheme Other
主題 Chondroitin sulfate proteoglycan
キーワード
主題Scheme Other
主題 Keratan sulfate proteoglycan
キーワード
主題Scheme Other
主題 Rat
抄録
内容記述 Background: Chondroitin sulfate proteoglycans are major inhibitory molecules for neural plasticity under both physiological and pathological conditions. The chondroitin sulfate degrading enzyme chondroitinase ABC promotes functional recovery after spinal cord injury, and restores experience-dependent plasticity, such as ocular dominance plasticity and fear erasure plasticity, in adult rodents. These data suggest that the sugar chain in a proteoglycan moiety is essential for the inhibitory activity of proteoglycans. However, the significance of the core protein has not been studied extensively. Furthermore, considering that chondroitinase ABC is derived from bacteria, a mammalian endogenous enzyme which can inactivate the proteoglycans' activity is desirable for clinical use. Methods: The degradation activity of ADAMTS-4 was estimated for the core proteins of chondroitin sulfate proteoglycans, that is, brevican, neurocan and phosphacan. To evaluate the biological significance of ADMATS-4 activity, an in vitro neurite growth assay and an in vivo neuronal injury model, spinal cord contusion injury, were employed. Results: ADAMTS-4 digested proteoglycans, and reversed their inhibition of neurite outgrowth. Local administration of ADAMTS-4 significantly promoted motor function recovery after spinal cord injury. Supporting these findings, the ADAMTS-4-treated spinal cord exhibited enhanced axonal regeneration/sprouting after spinal cord injury. Conclusions: Our data suggest that the core protein in a proteoglycan moiety is also important for the inhibition of neural plasticity, and provides a potentially safer tool for the treatment of neuronal injuries.
内容記述タイプ Abstract
出版者
出版者 BioMed Central
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1742-2094
書誌情報 Journal of Neuroinflammation

巻 9, p. 53-53, 発行日 2012-03-15
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.1186/1742-2094-9-53
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25530
識別子タイプ HDL
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