WEKO3
アイテム
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury
http://hdl.handle.net/2237/25530
http://hdl.handle.net/2237/25530e971f8f4-8bfd-4f4f-be0a-4b55d143c568
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
art_A10_1186_F1742-2094-9-53.pdf (396.5 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-26 | |||||
| タイトル | ||||||
| タイトル | The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury | |||||
| 言語 | en | |||||
| 著者 |
Tauchi, Ryoji
× Tauchi, Ryoji× Imagama, Shiro× Natori, Takamitsu× Ohgomori, Tomohiro× Muramoto, Akio× Shinjo, Ryuichi× Matsuyama, Yukihiro× Ishiguro, Naoki× Kadomatsu, Kenji |
|||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ADAMTS-4 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Spinal cord injury | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Extracellular matrix | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chondroitin sulfate proteoglycan | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Keratan sulfate proteoglycan | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Chondroitin sulfate proteoglycans are major inhibitory molecules for neural plasticity under both physiological and pathological conditions. The chondroitin sulfate degrading enzyme chondroitinase ABC promotes functional recovery after spinal cord injury, and restores experience-dependent plasticity, such as ocular dominance plasticity and fear erasure plasticity, in adult rodents. These data suggest that the sugar chain in a proteoglycan moiety is essential for the inhibitory activity of proteoglycans. However, the significance of the core protein has not been studied extensively. Furthermore, considering that chondroitinase ABC is derived from bacteria, a mammalian endogenous enzyme which can inactivate the proteoglycans' activity is desirable for clinical use. Methods: The degradation activity of ADAMTS-4 was estimated for the core proteins of chondroitin sulfate proteoglycans, that is, brevican, neurocan and phosphacan. To evaluate the biological significance of ADMATS-4 activity, an in vitro neurite growth assay and an in vivo neuronal injury model, spinal cord contusion injury, were employed. Results: ADAMTS-4 digested proteoglycans, and reversed their inhibition of neurite outgrowth. Local administration of ADAMTS-4 significantly promoted motor function recovery after spinal cord injury. Supporting these findings, the ADAMTS-4-treated spinal cord exhibited enhanced axonal regeneration/sprouting after spinal cord injury. Conclusions: Our data suggest that the core protein in a proteoglycan moiety is also important for the inhibition of neural plasticity, and provides a potentially safer tool for the treatment of neuronal injuries. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1186/1742-2094-9-53 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1742-2094 | |||||
| 書誌情報 |
en : Journal of Neuroinflammation 巻 9, p. 53-53, 発行日 2012-03-15 |
|||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1186/1742-2094-9-53 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25530 | |||||
| 識別子タイプ | HDL | |||||
