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Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis
http://hdl.handle.net/2237/25531
http://hdl.handle.net/2237/2553158666bd1-e358-4d8e-b9ac-f89bbecb2b5c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
cddis2013479a.pdf (3.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-01-27 | |||||
| タイトル | ||||||
| タイトル | Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis | |||||
| 言語 | en | |||||
| 著者 |
Matsui, H
× Matsui, H× Ohgomori, T× Natori, T× Miyamoto, K× Kusunoki, S× Sakamoto, K× Ishiguro, N× Imagama, S× Kadomatsu, K |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/ licenses/by/3.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | experimental autoimmune neuritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | keratan sulfate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microglia | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Experimental autoimmune neuritis (EAN) is an animal model of Guillain–Barré syndrome, an inflammatory demyelination disease of the peripheral nervous system. Although this disease has been extensively studied on peripheral nerves, the pathology of the central nervous system has not been fully understood. Previous studies demonstrate that expression of keratan sulfate (KS), the sugar chain of proteoglycan, is associated with activated microglia/macrophages accumulated after neuronal injuries. Unexpectedly, we found here that KS is rather diminished in rat EAN. KS was restrictively expressed in microglia in the spinal cord of normal rats. KS was positive in 50% microglia in the ventral horn and 20% in the dorsal horn. In EAN, microglia increased in number and expressed the activation marker CD68, but KS expression was abolished. Concomitantly, pro-inflammatory cytokines, i.e., interferon (IFN)-γ, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, were increased in the spinal cord of EAN rats, whereas anti-inflammatory cytokines, such as IL-4 and IL-10, were decreased. In addition, silencing of KSGal6ST attenuated KS expression on the primary cultured microglia and upregulated expression of some activation markers (TNF-α, IL-1β, and iNOS) under the stimulation with lipopolysaccharide and IFN-γ. This study demonstrates for the first time a close association of EAN and disappearance of KS on microglia. KS expression could be a useful marker to evaluate the status of polyneuropathy. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | nature | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/cddis.2013.479 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2041-4889 | |||||
| 書誌情報 |
en : Cell Death and Disease 巻 4, p. e946-e946, 発行日 2013-12-05 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1038/cddis.2013.479 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25531 | |||||
| 識別子タイプ | HDL | |||||
