{"_buckets": {"deposit": "9a9396b1-67c2-4322-88c2-322d82dbe417"}, "_deposit": {"id": "23340", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "23340"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00023340", "sets": ["501"]}, "author_link": ["69176", "69177", "69178", "69179", "69180", "69181", "69182", "69183", "69184", "69185", "69186"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03-07", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "e525", "bibliographicPageStart": "e525", "bibliographicVolumeNumber": "4", "bibliographic_titles": [{"bibliographic_title": "Cell Death and Disease", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Minocycline is commonly used to inhibit microglial activation. It is widely accepted that activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory (M2) functions. The in vivo status of activated microglia is probably on a continuum between these two extreme states. However, the mechanisms regulating microglial polarity remain elusive. Here, we addressed this question focusing on minocycline. We used SOD1G93A mice as a model, which exhibit the motor neuron-specific neurodegenerative disease, amyotrophic lateral sclerosis. Administration of minocycline attenuated the induction of the expression of M1 microglia markers during the progressive phase, whereas it did not affect the transient enhancement of expression of M2 microglia markers during the early pathogenesis phase. This selective inhibitory effect was confirmed using primary cultured microglia stimulated by lipopolysaccharide (LPS) or interleukin (IL)-4, which induced M1 or M2 polarization, respectively. Furthermore, minocycline inhibited the upregulation of NF-κB in the LPS-stimulated primary cultured microglia and in the spinal cord of SOD1G93A mice. On the other hand, IL-4 did not induce upregulation of NF-κB. This study indicates that minocycline selectively inhibits the microglia polarization to a proinflammatory state, and provides a basis for understanding pathogeneses of many diseases accompanied by microglial activation.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1038/cddis.2013.54"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/25532"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "nature", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/cddis.2013.54", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/ licenses/by/3.0/", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-4889", "subitem_source_identifier_type": "EISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kobayashi, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69176", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imagama, S", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69177", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohgomori, T", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69178", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69179", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uchimura, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69180", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69181", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirakawa, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69182", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeuchi, H", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69183", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzumura, A", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69184", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiguro, N", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69185", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kadomatsu, K", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "69186", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "cddis201354a.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2700000.0, "url": {"label": "cddis201354a.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/23340/files/cddis201354a.pdf"}, "version_id": "d96736d4-9cfd-4656-9b21-885918ab478c"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Minocycline selectively inhibits M1 polarization of microglia", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Minocycline selectively inhibits M1 polarization of microglia", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/25532", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-01-27"}, "publish_date": "2017-01-27", "publish_status": "0", "recid": "23340", "relation": {}, "relation_version_is_last": true, "title": ["Minocycline selectively inhibits M1 polarization of microglia"], "weko_shared_id": -1}