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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms

http://hdl.handle.net/2237/25533
http://hdl.handle.net/2237/25533
37e7c429-a84c-40be-8616-d67ddad14d4e
名前 / ファイル ライセンス アクション
JCI59251.pdf JCI59251.pdf (5.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-27
タイトル
タイトル Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms
言語 en
著者 Sakai, Kiyoshi

× Sakai, Kiyoshi

WEKO 69187

en Sakai, Kiyoshi

Search repository
Yamamoto, Akihito

× Yamamoto, Akihito

WEKO 69188

en Yamamoto, Akihito

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Matsubara, Kohki

× Matsubara, Kohki

WEKO 69189

en Matsubara, Kohki

Search repository
Nakamura, Shoko

× Nakamura, Shoko

WEKO 69190

en Nakamura, Shoko

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Naruse, Mami

× Naruse, Mami

WEKO 69191

en Naruse, Mami

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Yamagata, Mari

× Yamagata, Mari

WEKO 69192

en Yamagata, Mari

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Sakamoto, Kazuma

× Sakamoto, Kazuma

WEKO 69193

en Sakamoto, Kazuma

Search repository
Tauchi, Ryoji

× Tauchi, Ryoji

WEKO 69194

en Tauchi, Ryoji

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Wakao, Norimitsu

× Wakao, Norimitsu

WEKO 69195

en Wakao, Norimitsu

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Imagama, Shiro

× Imagama, Shiro

WEKO 69196

en Imagama, Shiro

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Hibi, Hideharu

× Hibi, Hideharu

WEKO 69197

en Hibi, Hideharu

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Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 69198

en Kadomatsu, Kenji

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Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 69199

en Ishiguro, Naoki

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Ueda, Minoru

× Ueda, Minoru

WEKO 69200

en Ueda, Minoru

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 Spinal cord injury (SCI) often leads to persistent functional deficits due to loss of neurons and glia and to limited axonal regeneration after injury. Here we report that transplantation of human dental pulp stem cells into the completely transected adult rat spinal cord resulted in marked recovery of hind limb locomotor functions. Transplantation of human bone marrow stromal cells or skin-derived fibroblasts led to substantially less recovery of locomotor function. The human dental pulp stem cells exhibited three major neuroregenerative activities. First, they inhibited the SCI-induced apoptosis of neurons, astrocytes, and oligodendrocytes, which improved the preservation of neuronal filaments and myelin sheaths. Second, they promoted the regeneration of transected axons by directly inhibiting multiple axon growth inhibitors, including chondroitin sulfate proteoglycan and myelin-associated glycoprotein, via paracrine mechanisms. Last, they replaced lost cells by differentiating into mature oligodendrocytes under the extreme conditions of SCI. Our data demonstrate that tooth-derived stem cells may provide therapeutic benefits for treating SCI through both cell-autonomous and paracrine neuroregenerative activities.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 American Society for Clinical Investigation
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1172/JCI59251
ISSN
収録物識別子タイプ PISSN
収録物識別子 0021-9738
書誌情報 en : The Journal of Clinical Investigation

巻 122, 号 1, p. 80-90, 発行日 2012-01
著者版フラグ
値 publisher
URI
識別子 http://doi.org/10.1172/JCI59251
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25533
識別子タイプ HDL
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