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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

McmA-dependent and -independent regulatory systems governing expression of ClrB-regulated cellulase and hemicellulase genes in Aspergillus nidulans

http://hdl.handle.net/2237/25576
http://hdl.handle.net/2237/25576
86f2a9d5-b0a9-4bd3-8b3e-72e99295009a
名前 / ファイル ライセンス アクション
ClrB-McmA_rev.pdf ClrB-McmA_rev.pdf ファイル公開:2017/12/01 (1.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-02-15
タイトル
タイトル McmA-dependent and -independent regulatory systems governing expression of ClrB-regulated cellulase and hemicellulase genes in Aspergillus nidulans
言語 en
著者 Li, Nuo

× Li, Nuo

WEKO 69317

en Li, Nuo

Search repository
Kunitake, Emi

× Kunitake, Emi

WEKO 69318

en Kunitake, Emi

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Aoyama, Miki

× Aoyama, Miki

WEKO 69319

en Aoyama, Miki

Search repository
Ogawa, Masahiro

× Ogawa, Masahiro

WEKO 69320

en Ogawa, Masahiro

Search repository
Kanamaru, Kyoko

× Kanamaru, Kyoko

WEKO 69321

en Kanamaru, Kyoko

Search repository
Kimura, Makoto

× Kimura, Makoto

WEKO 69322

en Kimura, Makoto

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Koyama, Yasuji

× Koyama, Yasuji

WEKO 69323

en Koyama, Yasuji

Search repository
Kobayashi, Tetsuo

× Kobayashi, Tetsuo

WEKO 69324

en Kobayashi, Tetsuo

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Li, N., Kunitake, E., Aoyama, M., Ogawa, M., Kanamaru, K., Kimura, M., Koyama, Y. and Kobayashi, T. (2016), McmA-dependent and -independent regulatory systems governing expression of ClrB-regulated cellulase and hemicellulase genes in Aspergillus nidulans. Molecular Microbiology, 102: 810–826. doi:10.1111/mmi.13493<br/>], which has been published in final form at [http://doi.org/10.1111/mmi.13493]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Fungal cellulolytic and hemicellulolytic enzymes are promising tools for industrial hydrolysis of cellulosic biomass; however, the regulatory network underlying their production is not well understood. The recent discovery of the transcriptional activators ClrB and McmA in Aspergillus nidulans implied a novel regulatory mechanism driven by their interaction, experimental evidence for which was obtained from transcriptional and DNA-binding analyses in this study. It was found that ClrB was essential for induced expression of all the genes examined in this study, while McmA dependency of their expression was gene-dependent. DNA-binding studies revealed McmA assisted in the recruitment of ClrB to the cellulose-responsive element (CeRE) in the promoters of eglA and eglB, expression of which was significantly reduced in the mcmA mutant. The CCG triplet within the CeRE served as the recognition sequence for the ClrB monomer. In contrast, ClrB did not require McmA for binding as a homodimer to the CGGN8CCG sequences in the promoter of mndB, expression of which was affected less in the mcmA mutant than in all other examined genes. Thus, there are two types of ClrB-mediated regulation: McmA-assisted and McmA-independent. This novel McmA–ClrB synergistic system provides new insights into the complex regulatory network involved in cellulase and hemicellulase production.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/mmi.13493
ISSN
収録物識別子タイプ PISSN
収録物識別子 0950-382X
書誌情報 en : Molecular Microbiology

巻 102, 号 5, p. 810-826, 発行日 2016-12
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1111/mmi.13493
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25576
識別子タイプ HDL
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