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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Non-thermal plasma prevents progression of endometriosis in mice

http://hdl.handle.net/2237/25581
http://hdl.handle.net/2237/25581
a04e8e4e-9583-4aea-bbb6-440f13bee136
名前 / ファイル ライセンス アクション
Ishida_Plasma_endometriosis_052516_FFB.pdf Ishida_Plasma_endometriosis_052516_FFB.pdf ファイル公開:2017/08/08 (4.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-02-16
タイトル
タイトル Non-thermal plasma prevents progression of endometriosis in mice
言語 en
著者 Ishida, Chiharu

× Ishida, Chiharu

WEKO 69343

en Ishida, Chiharu

Search repository
Mori, Masahiko

× Mori, Masahiko

WEKO 69344

en Mori, Masahiko

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Nakamura, Kae

× Nakamura, Kae

WEKO 69345

en Nakamura, Kae

Search repository
Tanaka, Hiromasa

× Tanaka, Hiromasa

WEKO 69346

en Tanaka, Hiromasa

Search repository
Mizuno, Masaaki

× Mizuno, Masaaki

WEKO 69347

en Mizuno, Masaaki

Search repository
Hori, Masaru

× Hori, Masaru

WEKO 69348

en Hori, Masaru

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Iwase, Akira

× Iwase, Akira

WEKO 69349

en Iwase, Akira

Search repository
Kikkawa, Fumitaka

× Kikkawa, Fumitaka

WEKO 69350

en Kikkawa, Fumitaka

Search repository
Toyokuni, Shinya

× Toyokuni, Shinya

WEKO 69351

en Toyokuni, Shinya

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Free Radical Research on 08/08/2016, available online: http://www.tandfonline.com/10.1080/10715762.2016.1211273.
キーワード
主題Scheme Other
主題 Endometriosis
キーワード
主題Scheme Other
主題 mouse model
キーワード
主題Scheme Other
主題 non-thermal plasma
キーワード
主題Scheme Other
主題 oxidative stress
抄録
内容記述 Endometriosis is observed in ∼10% of reproductive age women. Ovarian endometriosis not only causes dysmenorrhea but also causes infertility and a high risk of adenocarcinoma. Due to its scattered nature, complete surgical resection is difficult. Endometriosis consists of glandular and stromal cells. Previously, we showed that endometrial stromal cells (ESCs) play a role in the protection against pathologic events caused by monthly repeated hemorrhage. Here, we undertook a preclinical study of non-thermal plasma (NTP) as a surgical treatment of endometriosis. Epithelial cells were most sensitive to NTP-activated medium in vitro, whereas ectopic ESCs were most resistant. We then transplanted excised uteruses into BALB/c mice from donors of the same strain with estradiol supplementation. Four weeks after the transplantation, we exposed NTP to each endometriotic lesion after laparotomy. Immunohistochemical analysis revealed that immediately after NTP exposure, epithelial cells exhibited significantly higher levels of nuclear immunostaining for 8-hydroxy-2′-deoxyguanosine than did stromal cells. Four weeks after NTP exposure, the total surface area consisting of endometriotic cysts was significantly smaller with less epithelial proliferative activity than the helium-exposed control, whereas the number of endometriotic lesions had not changed. Therefore, NTP exposure may be useful to prevent the progression and recurrence of endometriosis.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1080/10715762.2016.1211273
ISSN
収録物識別子タイプ PISSN
収録物識別子 1071-5762
書誌情報 en : Free Radical Research

巻 50, 号 10, p. 1131-1139, 発行日 2016-08-08
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1080/10715762.2016.1211273
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25581
識別子タイプ HDL
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