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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 79(1)

Retrospective survey and evaluation of first-line antibiotics for chemotherapy-induced febrile neutropenia in patients with acute myeloid leukemia

https://doi.org/10.18999/nagjms.79.1.17
https://doi.org/10.18999/nagjms.79.1.17
e9b4695b-af95-4bfe-9cd0-c516d98a4879
名前 / ファイル ライセンス アクション
12_Mukoyama.pdf 12_Mukoyama.pdf (202.0 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-23
タイトル
タイトル Retrospective survey and evaluation of first-line antibiotics for chemotherapy-induced febrile neutropenia in patients with acute myeloid leukemia
著者 Mukoyama, Naoki

× Mukoyama, Naoki

WEKO 69461

Mukoyama, Naoki

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Nakashima, Marie

× Nakashima, Marie

WEKO 69462

Nakashima, Marie

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Miyamura, Koichi

× Miyamura, Koichi

WEKO 69463

Miyamura, Koichi

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Yoshimi, Akira

× Yoshimi, Akira

WEKO 69464

Yoshimi, Akira

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Noda, Yukihiro

× Noda, Yukihiro

WEKO 69465

Noda, Yukihiro

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Mori, Kazuhiro

× Mori, Kazuhiro

WEKO 69466

Mori, Kazuhiro

Search repository
キーワード
主題Scheme Other
主題 febrile neutropenia
キーワード
主題Scheme Other
主題 acute myeloid leukemia
キーワード
主題Scheme Other
主題 first-line antibiotics
抄録
内容記述 Patients with acute leukemia are susceptible to chemotherapy-induced severe myelosuppression, and therefore are at a high risk for febrile neutropenia (FN). In such cases, the use of broad-spectrum antibiotics such as fourth-generation cephalosporins and carbapenems is recommended as first-line antimicrobial treatment; however, the effectiveness of these agents in patients with acute myeloid leukemia (AML) has not been investigated in detail. We retrospectively examined and evaluated the effectiveness of first-line antibiotic treatment regimens for chemotherapy-induced FN in patients with AML in Japanese Red Cross Nagoya Daiichi Hospital. The evaluated first-line treatment regimens were as follows: cefozopran (CZOP) + amikacin (AMK) in 38 cases, cefepime (CFPM) alone in 2 cases, CFPM + AMK in 2 cases, piperacillin (PIPC) + AMK in 2 cases, and CZOP alone in 1 case. Additionally, prophylactic antifungal agents were administered in all cases. Markedly effective, effective, moderately effective, and ineffective responses occurred in 31.1%, 8.9%, 8.9%, and 51.1%, respectively, of the treated cases. The response rate, defined as the combination of markedly effective and effective outcomes, was 40.0%. In 11 cases, impairment of renal functions were observed, and they were associated with combination treatments including AMK; nine of these were associated with a glycopeptide. The combination of CZOP with AMK (84.4%) was the most commonly used first-line treatment for FN in patients with AML; carbapenem or tazobactam/PIPC has never been used for treatment of such cases. Our findings demonstrate that fourth-generation cephems will be an effective first-line treatment for FN in patients with AML in our hospital.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.79.1.17
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 79, 号 1, p. 17-26, 発行日 2017-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/791.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/25617
識別子タイプ HDL
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