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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 79(1)

[18F]Fluorodeoxyglucose uptake by positron emission tomography predicts outcomes for oropharyngeal and hypopharyngeal cancer treated with definitive radiotherapy

https://doi.org/10.18999/nagjms.79.1.27
https://doi.org/10.18999/nagjms.79.1.27
0f930871-f786-4085-adc0-6dd312076ce8
名前 / ファイル ライセンス アクション
13_Isihara.pdf 13_Isihara.pdf (329.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-23
タイトル
タイトル [18F]Fluorodeoxyglucose uptake by positron emission tomography predicts outcomes for oropharyngeal and hypopharyngeal cancer treated with definitive radiotherapy
著者 Ishihara, Takeaki

× Ishihara, Takeaki

WEKO 69467

Ishihara, Takeaki

Search repository
Kitajima, Kazuhiro

× Kitajima, Kazuhiro

WEKO 69468

Kitajima, Kazuhiro

Search repository
Suenaga, Yuko

× Suenaga, Yuko

WEKO 69469

Suenaga, Yuko

Search repository
Ejima, Yasuo

× Ejima, Yasuo

WEKO 69470

Ejima, Yasuo

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Komatsu, Hirokazu

× Komatsu, Hirokazu

WEKO 69471

Komatsu, Hirokazu

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Otsuki, Naoki

× Otsuki, Naoki

WEKO 69472

Otsuki, Naoki

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Nibu, Ken-ichi

× Nibu, Ken-ichi

WEKO 69473

Nibu, Ken-ichi

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Kiyota, Naomi

× Kiyota, Naomi

WEKO 69474

Kiyota, Naomi

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Takahashi, Satoru

× Takahashi, Satoru

WEKO 69475

Takahashi, Satoru

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Sasaki, Ryohei

× Sasaki, Ryohei

WEKO 69476

Sasaki, Ryohei

Search repository
キーワード
主題Scheme Other
主題 pharyngeal cancer
キーワード
主題Scheme Other
主題 prognostic predictor
キーワード
主題Scheme Other
主題 definitive radiotherapy
キーワード
主題Scheme Other
主題 18F-FDG-PET
キーワード
主題Scheme Other
主題 standardized uptake value (SUV)
抄録
内容記述 This study evaluated the prognostic significance of the maximum standardized uptake value of the primary site (pSUVmax) in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of patients with oropharyngeal or hypopharyngeal cancer who were treated using definitive radiotherapy. The study included 86 patients who were primarily treated with radiotherapy for oropharyngeal or hypopharyngeal cancer. Sixty-nine patients underwent concurrent chemotherapy. The associations between pre-treatment pSUVmax and treatment outcomes were evaluated. The most appropriate pSUVmax cut-off value for predicting disease-free survival (DFS) and local control (LC) was selected using receiver operating characteristic (ROC) curves. The median follow-up time for surviving patients was 60 months, while the median survival time in the entire patient cohort was 55 months. A pSUVmax cut-off value of 9.0 showed the best discriminative performance. Five-year OS and DFS rates were 65.9% and 60.0%, respectively. In univariate analyses, pSUVmax (p = 0.009), T-stage (p = 0.001), N-stage (p = 0.039), and clinical stage (p = 0.017) were identified as significant prognostic predictors for DFS. The multivariate analysis did not identify any statistically significant factors, but the association between pSUVmax and DFS was borderline significant (p = 0.055). Interestingly, pSUVmax was predictive of local controllability in T1–T2 disease (p = 0.024), but there was no significant association for T3–T4 disease (p = 0.735). In this study, pSUVmax was predictive of DFS and LC in patients with oropharyngeal or hypopharyngeal cancer that was treated with definitive radiotherapy. pSUVmax was strongly associated with LC in T1–T2 disease.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.79.1.27
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 79, 号 1, p. 27-36, 発行日 2017-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/791.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/25618
識別子タイプ HDL
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