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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy

http://hdl.handle.net/2237/25733
http://hdl.handle.net/2237/25733
326ffb2b-6a1d-45f3-9c56-d4ef97cea8e6
名前 / ファイル ライセンス アクション
Manuscript.pdf Manuscript.pdf ファイル公開:2017/12/01 (739.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-03-21
タイトル
タイトル Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy
言語 en
著者 Sawamura, Akinori

× Sawamura, Akinori

WEKO 69895

en Sawamura, Akinori

Search repository
Okumura, Takahiro

× Okumura, Takahiro

WEKO 69896

en Okumura, Takahiro

Search repository
Takeshita, Kyosuke

× Takeshita, Kyosuke

WEKO 69897

en Takeshita, Kyosuke

Search repository
Watanabe, Naoki

× Watanabe, Naoki

WEKO 69898

en Watanabe, Naoki

Search repository
Kano, Naoaki

× Kano, Naoaki

WEKO 69899

en Kano, Naoaki

Search repository
Mori, Hiroaki

× Mori, Hiroaki

WEKO 69900

en Mori, Hiroaki

Search repository
Fukaya, Kenji

× Fukaya, Kenji

WEKO 69901

en Fukaya, Kenji

Search repository
Morimoto, Ryota

× Morimoto, Ryota

WEKO 69902

en Morimoto, Ryota

Search repository
Hirashiki, Akihiro

× Hirashiki, Akihiro

WEKO 69903

en Hirashiki, Akihiro

Search repository
Bando, Kureishi Yasuko

× Bando, Kureishi Yasuko

WEKO 69904

en Bando, Kureishi Yasuko

Search repository
Murohara, Toyoaki

× Murohara, Toyoaki

WEKO 69905

en Murohara, Toyoaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 ‘This is the peer-reviewed but unedited manuscript version of the following article: [Cardiology. v.136, n.1, 2017, p.1-9 (DOI: 10.1159/000446868)]. The final, published version is available at http://www.karger.com/?doi=10.1159/000446868.’
キーワード
主題Scheme Other
主題 Dilated cardiomyopathy
キーワード
主題Scheme Other
主題 Prognosis
キーワード
主題Scheme Other
主題 Ambulatory blood pressure monitoring
キーワード
主題Scheme Other
主題 Circadian rhythm
抄録
内容記述 Objectives: An abnormal circadian blood pressure (BP) profile is considered a risk factor for cardiovascular disease. However, its significance in heart failure patients with nonischemic etiology is unknown. Herein, we investigated the prognostic value of a circadian BP profile in patients with nonischemic dilated cardiomyopathy (NIDCM). Methods: We enrolled 114 NIDCM patients (76 males, mean age 53.1 years). The percent nighttime BP fall (%NBPF) was defined using ambulatory BP monitoring as a percent decrease in mean systolic BP in nighttime from daytime. All patients were divided into three groups: dipper (%NBPF ≥10), non-dipper (0 ≤ %NBPF < 10), and riser (%NBPF <0). Results: Riser patients had the highest serum creatinine levels (dipper, 0.78 ± 0.20 mg/dl; non-dipper, 0.85 ± 0.21 mg/dl; riser, 0.99 ± 0.23 mg/dl; p = 0.006). In survival analysis, riser patients had the highest cumulative cardiac-related deaths (log-rank, p = 0.001), which was an independent predictor of cardiac-related deaths (hazard ratio, 12.6; 95% confidence interval, 1.76-253; p = 0.01). Multivariate analysis revealed that the norepinephrine level at 24-hour collected urine (24 h U-NE) and the serum creatinine level were independent determinants of %NBPF (adjusted R2 = 0.20; 24 h U-NE, p = 0.0001; serum creatinine, p = 0.04). Conclusions: The riser profile was associated with poor prognosis of NIDCM, which may reflect impaired sympathetic nervous system activity. Evaluating the circadian BP profile may be useful for risk stratification in NIDCM patients.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Karger
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1159/000446868
ISSN
収録物識別子タイプ PISSN
収録物識別子 0008-6312
書誌情報 en : Cardiology

巻 136, 号 1, p. 1-9, 発行日 2016-12
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1159/000446868
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25733
識別子タイプ HDL
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