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Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy
http://hdl.handle.net/2237/25733
http://hdl.handle.net/2237/25733326ffb2b-6a1d-45f3-9c56-d4ef97cea8e6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Manuscript.pdf ファイル公開：2017/12/01 (739.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-03-21 | |||||
| タイトル | ||||||
| タイトル | Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy | |||||
| 言語 | en | |||||
| 著者 |
Sawamura, Akinori
× Sawamura, Akinori× Okumura, Takahiro× Takeshita, Kyosuke× Watanabe, Naoki× Kano, Naoaki× Mori, Hiroaki× Fukaya, Kenji× Morimoto, Ryota× Hirashiki, Akihiro× Bando, Kureishi Yasuko× Murohara, Toyoaki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | ‘This is the peer-reviewed but unedited manuscript version of the following article: [Cardiology. v.136, n.1, 2017, p.1-9 (DOI: 10.1159/000446868)]. The final, published version is available at http://www.karger.com/?doi=10.1159/000446868.’ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dilated cardiomyopathy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prognosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ambulatory blood pressure monitoring | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Circadian rhythm | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: An abnormal circadian blood pressure (BP) profile is considered a risk factor for cardiovascular disease. However, its significance in heart failure patients with nonischemic etiology is unknown. Herein, we investigated the prognostic value of a circadian BP profile in patients with nonischemic dilated cardiomyopathy (NIDCM). Methods: We enrolled 114 NIDCM patients (76 males, mean age 53.1 years). The percent nighttime BP fall (%NBPF) was defined using ambulatory BP monitoring as a percent decrease in mean systolic BP in nighttime from daytime. All patients were divided into three groups: dipper (%NBPF ≥10), non-dipper (0 ≤ %NBPF < 10), and riser (%NBPF <0). Results: Riser patients had the highest serum creatinine levels (dipper, 0.78 ± 0.20 mg/dl; non-dipper, 0.85 ± 0.21 mg/dl; riser, 0.99 ± 0.23 mg/dl; p = 0.006). In survival analysis, riser patients had the highest cumulative cardiac-related deaths (log-rank, p = 0.001), which was an independent predictor of cardiac-related deaths (hazard ratio, 12.6; 95% confidence interval, 1.76-253; p = 0.01). Multivariate analysis revealed that the norepinephrine level at 24-hour collected urine (24 h U-NE) and the serum creatinine level were independent determinants of %NBPF (adjusted R2 = 0.20; 24 h U-NE, p = 0.0001; serum creatinine, p = 0.04). Conclusions: The riser profile was associated with poor prognosis of NIDCM, which may reflect impaired sympathetic nervous system activity. Evaluating the circadian BP profile may be useful for risk stratification in NIDCM patients. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Karger | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1159/000446868 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0008-6312 | |||||
| 書誌情報 |
en : Cardiology 巻 136, 号 1, p. 1-9, 発行日 2016-12 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1159/000446868 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25733 | |||||
| 識別子タイプ | HDL | |||||
