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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

An autopsy case of cortical superficial siderosis with persistent abnormal behavior

http://hdl.handle.net/2237/25744
http://hdl.handle.net/2237/25744
9cccba59-5e2e-4647-945d-5eed3508052a
名前 / ファイル ライセンス アクション
s1-ln22637059.pdf s1-ln22637059.pdf ファイル公開:2017/12/01 (2.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-03-22
タイトル
タイトル An autopsy case of cortical superficial siderosis with persistent abnormal behavior
言語 en
著者 Torii, Youta

× Torii, Youta

WEKO 69966

en Torii, Youta

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Iritani, Shuji

× Iritani, Shuji

WEKO 69967

en Iritani, Shuji

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Fujishiro, Hiroshige

× Fujishiro, Hiroshige

WEKO 69968

en Fujishiro, Hiroshige

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Sekiguchi, Hirotaka

× Sekiguchi, Hirotaka

WEKO 69969

en Sekiguchi, Hirotaka

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Habuchi, Chikako

× Habuchi, Chikako

WEKO 69970

en Habuchi, Chikako

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Umeda, Kentaro

× Umeda, Kentaro

WEKO 69971

en Umeda, Kentaro

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Matsunaga, Shinji

× Matsunaga, Shinji

WEKO 69972

en Matsunaga, Shinji

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Mimuro, Maya

× Mimuro, Maya

WEKO 69973

en Mimuro, Maya

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Ozaki, Norio

× Ozaki, Norio

WEKO 69974

en Ozaki, Norio

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Yoshida, Mari

× Yoshida, Mari

WEKO 69975

en Yoshida, Mari

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Fujita, Kiyoshi

× Fujita, Kiyoshi

WEKO 69976

en Fujita, Kiyoshi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Torii, Y., Iritani, S., Fujishiro, H., Sekiguchi, H., Habuchi, C., Umeda, K., Matsunaga, S., Mimuro, M., Ozaki, N., Yoshida, M., and Fujita, K. (2016) An autopsy case of cortical superficial siderosis with persistent abnormal behavior. Neuropathology, 36: 544–550. doi: 10.1111/neup.12301.<br/>], which has been published in final form at [http://doi.org/10.1111/neup.12301]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 In recent years, MRI has revealed cortical superficial siderosis (cSS), which exhibits hemosiderin deposition in only the cortical surface. However, the associations between the histological findings and clinical symptoms of cSS remain unclear. We herein report an autopsy case of a 75-year-old Japanese man with cSS with persistent abnormal behavior according to cognitive impairment, hallucination and delusion. At 73 years of age, the patient presented with unusual behavior that indicated auditory hallucination and delusion. One year later, he was admitted to the hospital for malignant lymphoma. On admission, cognitive impairment was detected by a screening test. Soon after hospitalization, he presented with active delirium including visual hallucination and delusion. The patient's excited behavior was improved by the administration of a major tranquilizer. However, the abnormal behavior and cognitive impairment persisted. At 75 years of age, he died of heart failure. A neuropathological investigation revealed hemosiderin depositions in the superficial layer of the cortex in the medial and lateral frontal lobe, the lateral temporal lobe, the parietal lobe, and the medial and lateral occipital lobe. Neuritic plaques and diffuse plaques were extensively observed, which corresponded to Braak stage C and CERAD B, although NFTs were observed that corresponded to Braak stage II. Cortical amyloid angiopathy was not observed in any regions. Ischemic change of brain was also mild. Our report suggests that localized deposition of hemosiderin in the cortex might affect the manifestation of cognitive impairments and hallucination. Further clinicopathological studies are needed to clarify the clinical manifestations of patients with cSS.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/neup.12301
ISSN
収録物識別子タイプ PISSN
収録物識別子 0919-6544
書誌情報 en : Neuropathology

巻 36, 号 6, p. 544-550, 発行日 2016-12
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1111/neup.12301
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25744
識別子タイプ HDL
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