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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264

http://hdl.handle.net/2237/25872
01b35afa-1875-4d43-9efa-2e7c3f5ec838
名前 / ファイル ライセンス アクション
Higuchi-figs.pdf Higuchi-figs.pdf (498.0 kB)
GraphAbs.pdf GraphAbs.pdf (168.0 kB)
Higuchi-text.pdf Higuchi-text.pdf (255.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-03
タイトル
タイトル Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264
著者 Higuchi, Hiroshi

× Higuchi, Hiroshi

WEKO 70302

Higuchi, Hiroshi

Search repository
Shoji, Toru

× Shoji, Toru

WEKO 70303

Shoji, Toru

Search repository
Murase, Yusuke

× Murase, Yusuke

WEKO 70304

Murase, Yusuke

Search repository
Iijima, Shinji

× Iijima, Shinji

WEKO 70305

Iijima, Shinji

Search repository
Nishijima, Ken-ichi

× Nishijima, Ken-ichi

WEKO 70306

Nishijima, Ken-ichi

Search repository
権利
権利情報 (c)日本農芸化学会. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 05/11/2015, available online: http://dx.doi.org/10.1080/09168451.2015.1104238.
キーワード
主題Scheme Other
主題 lectin
キーワード
主題Scheme Other
主題 macrophages
キーワード
主題Scheme Other
主題 sialic acid
キーワード
主題Scheme Other
主題 IL-4
キーワード
主題Scheme Other
主題 RAW264
抄録
内容記述 Siglecs, an immunoglobulin-like lectin family that recognizes the sialic acid moiety, regulate various aspects of immune responses. In the present study, we investigated the effects of Siglecs on the macrophage cell line RAW264, which was stimulated with interleukin-4 (IL-4). The induction of arginase-1 (Arg1) by IL-4 was stronger in Siglec-9-expressing cells than in mock cells. Mutations in the cytoplasmic tyrosine-based inhibitory motifs in Siglec-9 markedly reduced the expression of Arg1. The phosphorylation of Akt by IL-4 and extracellular signal-regulated kinase (ERK) without IL-4 was stronger in Siglec-9-expressing cells, indicating the enhanced activation of the phosphatidylinositol 3 kinase (PI-3K) and mitogen-activated protein kinase kinase (MEK)/ERK pathways, respectively. The enhanced expression of Arg1 was inhibited by MEK inhibitors, but not by PI-3K inhibitor. These results indicate that Siglec-9 affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 in Siglec-9-expressing RAW264 cells.
内容記述タイプ Abstract
出版者
出版者 Taylor & Francis
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0916-8451
書誌情報 Bioscience, Biotechnology, and Biochemistry

巻 80, 号 3, p. 501-509, 発行日 2016
著者版フラグ
値 author
URI
識別子 http://dx.doi.org/10.1080/09168451.2015.1104238
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25872
識別子タイプ HDL
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