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Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264
http://hdl.handle.net/2237/25872
http://hdl.handle.net/2237/2587201b35afa-1875-4d43-9efa-2e7c3f5ec838
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Higuchi-figs.pdf (498.0 kB)
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GraphAbs.pdf (168.0 kB)
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Higuchi-text.pdf (255.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-03 | |||||
| タイトル | ||||||
| タイトル | Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264 | |||||
| 言語 | en | |||||
| 著者 |
Higuchi, Hiroshi
× Higuchi, Hiroshi× Shoji, Toru× Murase, Yusuke× Iijima, Shinji× Nishijima, Ken-ichi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | (c)日本農芸化学会. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 05/11/2015, available online: http://dx.doi.org/10.1080/09168451.2015.1104238. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lectin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | macrophages | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sialic acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IL-4 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RAW264 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Siglecs, an immunoglobulin-like lectin family that recognizes the sialic acid moiety, regulate various aspects of immune responses. In the present study, we investigated the effects of Siglecs on the macrophage cell line RAW264, which was stimulated with interleukin-4 (IL-4). The induction of arginase-1 (Arg1) by IL-4 was stronger in Siglec-9-expressing cells than in mock cells. Mutations in the cytoplasmic tyrosine-based inhibitory motifs in Siglec-9 markedly reduced the expression of Arg1. The phosphorylation of Akt by IL-4 and extracellular signal-regulated kinase (ERK) without IL-4 was stronger in Siglec-9-expressing cells, indicating the enhanced activation of the phosphatidylinositol 3 kinase (PI-3K) and mitogen-activated protein kinase kinase (MEK)/ERK pathways, respectively. The enhanced expression of Arg1 was inhibited by MEK inhibitors, but not by PI-3K inhibitor. These results indicate that Siglec-9 affects several different signaling pathways in IL-4-stimulated macrophages, which resulted in enhanced induction of Arg1 in Siglec-9-expressing RAW264 cells. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/09168451.2015.1104238 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0916-8451 | |||||
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry 巻 80, 号 3, p. 501-509, 発行日 2016 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1080/09168451.2015.1104238 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25872 | |||||
| 識別子タイプ | HDL | |||||
