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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Proposal of the Coagulation Score as a Predictor for Short-Term and Long-Term Outcomes of Patients with Resectable Gastric Cancer

http://hdl.handle.net/2237/26027
http://hdl.handle.net/2237/26027
83688bdc-e2d1-4f61-a6ea-42d4508558f1
名前 / ファイル ライセンス アクション
Proposal_of_the_Coagulation_Score_as_a_Predictor.pdf Proposal_of_the_Coagulation_Score_as_a_Predictor.pdf ファイル公開:2018/02/01 (984.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-19
タイトル
タイトル Proposal of the Coagulation Score as a Predictor for Short-Term and Long-Term Outcomes of Patients with Resectable Gastric Cancer
言語 en
著者 Kanda, Mitsuro

× Kanda, Mitsuro

WEKO 70739

en Kanda, Mitsuro

Search repository
Tanaka, Chie

× Tanaka, Chie

WEKO 70740

en Tanaka, Chie

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Kobayashi, Daisuke

× Kobayashi, Daisuke

WEKO 70741

en Kobayashi, Daisuke

Search repository
Mizuno, Akira

× Mizuno, Akira

WEKO 70742

en Mizuno, Akira

Search repository
Tanaka, Yuri

× Tanaka, Yuri

WEKO 70743

en Tanaka, Yuri

Search repository
Takami, Hideki

× Takami, Hideki

WEKO 70744

en Takami, Hideki

Search repository
Iwata, Naoki

× Iwata, Naoki

WEKO 70745

en Iwata, Naoki

Search repository
Hayashi, Masamichi

× Hayashi, Masamichi

WEKO 70746

en Hayashi, Masamichi

Search repository
Niwa, Yukiko

× Niwa, Yukiko

WEKO 70747

en Niwa, Yukiko

Search repository
Yamada, Suguru

× Yamada, Suguru

WEKO 70748

en Yamada, Suguru

Search repository
Fujii, Tsutomu

× Fujii, Tsutomu

WEKO 70749

en Fujii, Tsutomu

Search repository
Sugimoto, Hiroyuki

× Sugimoto, Hiroyuki

WEKO 70750

en Sugimoto, Hiroyuki

Search repository
Murotani, Kenta

× Murotani, Kenta

WEKO 70751

en Murotani, Kenta

Search repository
Fujiwara, Michitaka

× Fujiwara, Michitaka

WEKO 70752

en Fujiwara, Michitaka

Search repository
Kodera, Yasuhiro

× Kodera, Yasuhiro

WEKO 70753

en Kodera, Yasuhiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at Springer via http://doi.org/10.1245/s10434-016-5544-1
抄録
内容記述 Background: Systemic hemostasis and thrombosis activation has been implicated in tumor progression and metastasis. This study aimed to investigate the use of coagulation factors as a novel prediction method for postoperative outcomes after curative gastrectomy in patients with stage II/III gastric cancer (GC). Methods: Overall, 126 patients with stage II/III GC who underwent gastrectomy between May 2003 and February 2016 were eligible for inclusion in the study. We retrospectively evaluated the predictive value of preoperative platelet count and plasma fibrinogen and d-dimer levels, and coagulation score (0: fibrinogen and d-dimer both below upper limits; 1: either fibrinogen or d-dimer over upper limits; 2: both fibrinogen and d-dimer over upper limits) for short- and long-term outcomes. Results: Postoperative complications were significantly more frequent in patients with elevated preoperative d-dimer levels compared with those with normal d-dimer levels (26 vs. 10 %; p = 0.032). The prevalence of postoperative complications showed a stepwise increase in proportion to the coagulation score. Patients with a coagulation score of 2 had significantly larger tumors (p = 0.013) and significantly greater intraoperative blood loss (p = 0.004) than those who scored 0 or 1. Coagulation score showed the highest values distinguished high-risk patients in overall and disease-free survival, and a coagulation score of 2 was an independent prognostic factor for recurrence. Patients with a coagulation score of 2 experienced a significantly higher prevalence of liver metastasis as an initial recurrence than those who scored 0 or 1 (p = 0.019). Conclusions: The coagulation score is a simple and promising predictor for postoperative complications and recurrence after gastrectomy in stage II/III GC patients.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1245/s10434-016-5544-1
ISSN
収録物識別子タイプ PISSN
収録物識別子 1068-9265
書誌情報 en : Annals of Surgical Oncology

巻 24, 号 2, p. 502-509, 発行日 2017-02
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1245/s10434-016-5544-1
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26027
識別子タイプ HDL
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