ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Pharmacokinetic dose adjustment of 5-FU in modified FOLFOX7 plus bevacizumab for metastatic colorectal cancer in Japanese patients: a-JUST phase II clinical trial

http://hdl.handle.net/2237/26032
http://hdl.handle.net/2237/26032
9981590b-ad16-4693-8e9c-62bf881c82ca
名前 / ファイル ライセンス アクション
Pharmacokinetic_dose_adjustment_of_5-FU_in_modified_FOLFOX7.pdf Pharmacokinetic_dose_adjustment_of_5-FU_in_modified_FOLFOX7.pdf ファイル公開:2017/12/01 (745.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-19
タイトル
タイトル Pharmacokinetic dose adjustment of 5-FU in modified FOLFOX7 plus bevacizumab for metastatic colorectal cancer in Japanese patients: a-JUST phase II clinical trial
言語 en
著者 Denda, Tadamichi

× Denda, Tadamichi

WEKO 70810

en Denda, Tadamichi

Search repository
Kanda, Mitsuro

× Kanda, Mitsuro

WEKO 70811

en Kanda, Mitsuro

Search repository
Morita, Yoshitaka

× Morita, Yoshitaka

WEKO 70812

en Morita, Yoshitaka

Search repository
Kim, Ho Min

× Kim, Ho Min

WEKO 70813

en Kim, Ho Min

Search repository
Kashiwada, Tomomi

× Kashiwada, Tomomi

WEKO 70814

en Kashiwada, Tomomi

Search repository
Matsuda, Chu

× Matsuda, Chu

WEKO 70815

en Matsuda, Chu

Search repository
Fujieda, Shinji

× Fujieda, Shinji

WEKO 70816

en Fujieda, Shinji

Search repository
Nakata, Ken

× Nakata, Ken

WEKO 70817

en Nakata, Ken

Search repository
Murotani, Kenta

× Murotani, Kenta

WEKO 70818

en Murotani, Kenta

Search repository
Oba, Koji

× Oba, Koji

WEKO 70819

en Oba, Koji

Search repository
Sakamoto, Junichi

× Sakamoto, Junichi

WEKO 70820

en Sakamoto, Junichi

Search repository
Mishima, Hideyuki

× Mishima, Hideyuki

WEKO 70821

en Mishima, Hideyuki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at Springer via http://doi.org/10.1007/s00280-016-3184-6
抄録
内容記述タイプ Abstract
内容記述 Purpose: Dose adjustment of 5-fluorouracil (FU) based on pharmacokinetic monitoring has been shown to reduce toxicities and increase efficacy compared with dosing based on body surface area in patients with metastatic colorectal cancer (mCRC). We evaluated the efficacy and safety of pharmacokinetic dose adjustment of FU in a modified FOLFOX7 (mFOLFOX7) plus bevacizumab regimen in Japanese patients with previously untreated mCRC. Methods: This single-arm, multicenter phase II trial enrolled 48 patients with mCRC. Treatment consisted of 5 mg/kg intravenous bevacizumab followed by mFOLFOX7 (oxaliplatin 85 mg/m2 on day 1, infused leucovorin 200 mg/m2, followed by a 2400 mg/m2 infusion of FU for 46 h starting on day 1), repeated every 2 weeks. FU concentrations were measured by immunoassay between 18 and 36 h after the start of continuous FU infusion, and the FU dose was then adjusted if required in subsequent cycles. The primary endpoint was response rate. Results: The median initial area under the concentration–time curve for FU was 23 mg h/L. Twenty-nine patients (60%) achieved the target concentration at the first cycle, and all 48 achieved it within the fourth cycle. The overall frequency of grade 3/4 adverse effects was 38%, with no significant difference between patients who did and not require dose adjustments. The overall response rate was 48% (95% confidence intervals = 34–62%). The median progression-free and overall survival rates were 11.3 and 24.1 months, respectively. Conclusions: Pharmacokinetic dose adjustment of FU in mFOLFOX7 plus bevacizumab can optimize FU concentrations promptly and is safe in Japanese patients with mCRC.
言語 en
出版者
出版者 Springer
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00280-016-3184-6
ISSN
収録物識別子タイプ PISSN
収録物識別子 0344-5704
書誌情報 en : Cancer Chemotherapy and Pharmacology

巻 78, 号 6, p. 1253-1261, 発行日 2016-12
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s00280-016-3184-6
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26032
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 14:22:48.847118
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3