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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor

http://hdl.handle.net/2237/26045
http://hdl.handle.net/2237/26045
b08ec18b-87cf-48d6-91df-cd0077500fc9
名前 / ファイル ライセンス アクション
Ikuta.pdf Ikuta.pdf ファイル公開日:2018/01/15 (3.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-19
タイトル
タイトル Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor
言語 en
著者 Ikuta, Kunihiro

× Ikuta, Kunihiro

WEKO 70841

en Ikuta, Kunihiro

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Ota, Takehiro

× Ota, Takehiro

WEKO 70842

en Ota, Takehiro

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Zhuo, Lisheng

× Zhuo, Lisheng

WEKO 70843

en Zhuo, Lisheng

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Urakawa, Hiroshi

× Urakawa, Hiroshi

WEKO 70844

en Urakawa, Hiroshi

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Kozawa, Eiji

× Kozawa, Eiji

WEKO 70845

en Kozawa, Eiji

Search repository
Hamada, Shunsuke

× Hamada, Shunsuke

WEKO 70846

en Hamada, Shunsuke

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Kimata, Koji

× Kimata, Koji

WEKO 70847

en Kimata, Koji

Search repository
Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 70848

en Ishiguro, Naoki

Search repository
Nishida, Yoshihiro

× Nishida, Yoshihiro

WEKO 70849

en Nishida, Yoshihiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [kuta, K., Ota, T., Zhuo, L., Urakawa, H., Kozawa, E., Hamada, S., Kimata, K., Ishiguro, N. and Nishida, Y. (2017), Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor. Int. J. Cancer, 140: 469–479. doi:10.1002/ijc.30460], which has been published in final form at [http://doi.org/10.1002/ijc.30460]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in MPNST might suppress the tumorigenicity. The aim of our study was to investigate the antitumor effects of 4-methylumbelliferone (MU), an HA synthesis inhibitor, on human MPNST cells and tissues. The effects of MU on HA accumulation and tumorigenicity in MPNST cells were analyzed in the presence or absence of MU in an in vitro as well as in vivo xenograft model using human MPNST cell lines, sNF96.2 (primary recurrent) and sNF02.2 (metastatic). MU significantly inhibited cell proliferation, migration and invasion in both MPNST cell lines. HA binding protein (HABP) staining, particle exclusion assay and quantification of HA revealed that MU significantly decreased HA accumulation in the cytoplasms and pericellular matrices in both MPNST cell lines. The expression levels of HA synthase2 (HAS2) and HA synthase3 (HAS3) mRNA were downregulated after treatment with MU. MU induced apoptosis of sNF96.2 cells, but not sNF02.2 cells. MU administration significantly inhibited the tumor growth of sNF96.2 cells in the mouse xenograft model. To the best of our knowledge, our study demonstrates for the first time the antitumor effects of MU on human MPNST mediated by inhibition of HA synthesis. Our results suggest that MU may be a promising agent with novel antitumor mechanisms for MPNST.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/ijc.30460
ISSN
収録物識別子タイプ PISSN
収録物識別子 0020-7136
書誌情報 en : International Journal of Cancer

巻 140, 号 2, p. 469-479, 発行日 2017-01-15
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/ijc.30460
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26045
識別子タイプ HDL
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