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Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana
http://hdl.handle.net/2237/26267
http://hdl.handle.net/2237/262679ddb4375-13ed-4db0-8eeb-29fcc5f03b86
名前 / ファイル | ライセンス | アクション |
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Nambo_PCP.pdf ファイル公開:2017/11/01 (3.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-10 | |||||
タイトル | ||||||
タイトル | Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana | |||||
言語 | en | |||||
著者 |
Nambo, Masakazu
× Nambo, Masakazu× Kurihara, Daisuke× Yamada, Tomomi× Nishiwaki-Ohkawa, Taeko× Kadofusa, Naoya× Kimata, Yusuke× Kuwata, Keiko× Umeda, Masaaki× Ueda, Minako |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in [Plant & Cell Physiology] following peer review. The version of record [Plant & Cell Physiology. v.57, n.11, 2016, p.2255-2268] is available online at: https://doi.org/10.1093/pcp/pcw140. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Arabidopsis thaliana | |||||
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主題Scheme | Other | |||||
主題 | Cell division inhibitor | |||||
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主題Scheme | Other | |||||
主題 | Live-cell imaging | |||||
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主題Scheme | Other | |||||
主題 | Organic chemistry | |||||
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主題Scheme | Other | |||||
主題 | Tobacco BY-2 cell | |||||
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主題Scheme | Other | |||||
主題 | Triarylmethane | |||||
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内容記述 | Cell proliferation is crucial to the growth of multicellular organisms, and thus the proper control of cell division is important to prevent developmental arrest or overgrowth. Nevertheless, tools for controlling cell proliferation are still poor in plant. To develop novel tools, we focused on a specific compound family, triarylmethanes, whose members show various antiproliferative activities in animals. By combining organic chemistry to create novel and diverse compounds containing the triarylmethyl moiety and biological screens based on live-cell imaging of a fluorescently labeled tobacco Bright Yellow-2 (BY-2) culture cell line (Nicotiana tabacum), we isolated (3-furyl)diphenylmethane as a strong but partially reversible inhibitor of plant cell division. We also found that this agent had efficient antiproliferative activity in developing organs of Arabidopsis thaliana without causing secondary defects in cell morphology, and induced rapid cell division arrest independent of the cell cycle stage. Given that (3-furyl)diphenylmethane did not affect the growth of a human cell line (HeLa) and a budding yeast (Saccharomyces cerevisiae), it should act specifically on plants. Taking our results together, we propose that the combination of desired chemical synthesis and detailed biological analysis is an effective tool to create novel drugs, and that (3-furyl)diphenylmethane is a specific antiproliferative agent for plants. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Oxford University Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/pcp/pcw140 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0032-0781 | |||||
書誌情報 |
en : Plant & Cell Physiology 巻 57, 号 11, p. 2255-2268, 発行日 2016-11 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | https://doi.org/10.1093/pcp/pcw140 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26267 | |||||
識別子タイプ | HDL |