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  1. I300 トランスフォーマティブ生命分子研究所
  2. I300a 雑誌掲載論文
  3. 学術雑誌

Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana

http://hdl.handle.net/2237/26267
http://hdl.handle.net/2237/26267
9ddb4375-13ed-4db0-8eeb-29fcc5f03b86
名前 / ファイル ライセンス アクション
Nambo_PCP.pdf Nambo_PCP.pdf ファイル公開:2017/11/01 (3.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-05-10
タイトル
タイトル Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana
言語 en
著者 Nambo, Masakazu

× Nambo, Masakazu

WEKO 71407

en Nambo, Masakazu

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Kurihara, Daisuke

× Kurihara, Daisuke

WEKO 71408

en Kurihara, Daisuke

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Yamada, Tomomi

× Yamada, Tomomi

WEKO 71409

en Yamada, Tomomi

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Nishiwaki-Ohkawa, Taeko

× Nishiwaki-Ohkawa, Taeko

WEKO 71410

en Nishiwaki-Ohkawa, Taeko

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Kadofusa, Naoya

× Kadofusa, Naoya

WEKO 71411

en Kadofusa, Naoya

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Kimata, Yusuke

× Kimata, Yusuke

WEKO 71412

en Kimata, Yusuke

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Kuwata, Keiko

× Kuwata, Keiko

WEKO 71413

en Kuwata, Keiko

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Umeda, Masaaki

× Umeda, Masaaki

WEKO 71414

en Umeda, Masaaki

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Ueda, Minako

× Ueda, Minako

WEKO 71415

en Ueda, Minako

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Plant & Cell Physiology] following peer review. The version of record [Plant & Cell Physiology. v.57, n.11, 2016, p.2255-2268] is available online at: https://doi.org/10.1093/pcp/pcw140.
キーワード
主題Scheme Other
主題 Arabidopsis thaliana
キーワード
主題Scheme Other
主題 Cell division inhibitor
キーワード
主題Scheme Other
主題 Live-cell imaging
キーワード
主題Scheme Other
主題 Organic chemistry
キーワード
主題Scheme Other
主題 Tobacco BY-2 cell
キーワード
主題Scheme Other
主題 Triarylmethane
抄録
内容記述 Cell proliferation is crucial to the growth of multicellular organisms, and thus the proper control of cell division is important to prevent developmental arrest or overgrowth. Nevertheless, tools for controlling cell proliferation are still poor in plant. To develop novel tools, we focused on a specific compound family, triarylmethanes, whose members show various antiproliferative activities in animals. By combining organic chemistry to create novel and diverse compounds containing the triarylmethyl moiety and biological screens based on live-cell imaging of a fluorescently labeled tobacco Bright Yellow-2 (BY-2) culture cell line (Nicotiana tabacum), we isolated (3-furyl)diphenylmethane as a strong but partially reversible inhibitor of plant cell division. We also found that this agent had efficient antiproliferative activity in developing organs of Arabidopsis thaliana without causing secondary defects in cell morphology, and induced rapid cell division arrest independent of the cell cycle stage. Given that (3-furyl)diphenylmethane did not affect the growth of a human cell line (HeLa) and a budding yeast (Saccharomyces cerevisiae), it should act specifically on plants. Taking our results together, we propose that the combination of desired chemical synthesis and detailed biological analysis is an effective tool to create novel drugs, and that (3-furyl)diphenylmethane is a specific antiproliferative agent for plants.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/pcp/pcw140
ISSN
収録物識別子タイプ PISSN
収録物識別子 0032-0781
書誌情報 en : Plant & Cell Physiology

巻 57, 号 11, p. 2255-2268, 発行日 2016-11
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1093/pcp/pcw140
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26267
識別子タイプ HDL
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