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To clarify the clinical relevance of macrophage phenotypes in human glomerular diseases, we evaluated the renal accumulation of macrophages and plasma and urine levels of CD163, an M2 marker, in lupus nephritis (LN) patients. Methods: Kidney biopsies and plasma and urine samples were obtained from LN patients who underwent renal biopsy between 2008 and 2012. CD163+, CD68+ and CD204+ cells were counted in paraffin-embedded and frozen sections. LN histological activity was evaluated semiquantitatively using the biopsy activity index. Plasma and urinary soluble CD163 (sCD163) concentrations were also measured and evaluated for their significance as potential LN biomarkers. Results: Immunohistological analysis of glomeruli from LN patients revealed that \u003e60% of CD68+ macrophages had merged with CD163+ cells. The increased number of glomerular CD163+ macrophages was correlated with LN severity, as determined by the biopsy active index (r = 0.635). 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis

http://hdl.handle.net/2237/26288
http://hdl.handle.net/2237/26288
f543411c-d324-4d0e-88fe-080c2b912904
名前 / ファイル ライセンス アクション
endo-NDT.pdf endo-NDT.pdf ファイル公開:2017/12/09 (6.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-05-12
タイトル
タイトル Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis
言語 en
著者 Endo, Nobuhide

× Endo, Nobuhide

WEKO 71469

en Endo, Nobuhide

Search repository
Tsuboi, Naotake

× Tsuboi, Naotake

WEKO 71470

en Tsuboi, Naotake

Search repository
Furuhashi, Kazuhiro

× Furuhashi, Kazuhiro

WEKO 71471

en Furuhashi, Kazuhiro

Search repository
Shi, Yiqin

× Shi, Yiqin

WEKO 71472

en Shi, Yiqin

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Du, Qiuna

× Du, Qiuna

WEKO 71473

en Du, Qiuna

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Abe, Tomoko

× Abe, Tomoko

WEKO 71474

en Abe, Tomoko

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Hori, Mayuko

× Hori, Mayuko

WEKO 71475

en Hori, Mayuko

Search repository
Imaizumi, Takahiro

× Imaizumi, Takahiro

WEKO 71476

en Imaizumi, Takahiro

Search repository
Kim, Hangsoo

× Kim, Hangsoo

WEKO 71477

en Kim, Hangsoo

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Katsuno, Takayuki

× Katsuno, Takayuki

WEKO 71478

en Katsuno, Takayuki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Nephrology Dialysis Transplantation] following peer review. The version of record [Nephrology Dialysis Transplantation. v.31, n.12, 2016, p.2023-2033] is available online at: https://doi.org/10.1093/ndt/gfw214
キーワード
主題Scheme Other
主題 biomarker
キーワード
主題Scheme Other
主題 histopathology
キーワード
主題Scheme Other
主題 lupus nephritis
キーワード
主題Scheme Other
主題 macrophage
キーワード
主題Scheme Other
主題 surface marker
抄録
内容記述 Background: In addition to classically activated macrophages that have effector roles in tissue injury, alternatively activated M2 macrophages are involved in the resolution of inflammation in animal models of kidney disease. To clarify the clinical relevance of macrophage phenotypes in human glomerular diseases, we evaluated the renal accumulation of macrophages and plasma and urine levels of CD163, an M2 marker, in lupus nephritis (LN) patients. Methods: Kidney biopsies and plasma and urine samples were obtained from LN patients who underwent renal biopsy between 2008 and 2012. CD163+, CD68+ and CD204+ cells were counted in paraffin-embedded and frozen sections. LN histological activity was evaluated semiquantitatively using the biopsy activity index. Plasma and urinary soluble CD163 (sCD163) concentrations were also measured and evaluated for their significance as potential LN biomarkers. Results: Immunohistological analysis of glomeruli from LN patients revealed that >60% of CD68+ macrophages had merged with CD163+ cells. The increased number of glomerular CD163+ macrophages was correlated with LN severity, as determined by the biopsy active index (r = 0.635). Urinary (u-) sCD163 level was strongly correlated with glomerular CD163+ cell counts and histological disease score as well as urinary monocyte chemoattractant protein 1 levels (r = 0.638 and 0.592, respectively). Furthermore, the u-sCD163 level was higher in patients with active LN than in those with other diseases. Conclusions: Glomerular CD163+ macrophages are the predominant phenotype in the kidneys of lupus patients. These findings indicate that the u-sCD163 level can serve as a biomarker for macrophage-dependent glomerular inflammation in human LN.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/ndt/gfw214
ISSN
収録物識別子タイプ PISSN
収録物識別子 0931-0509
書誌情報 en : Nephrology Dialysis Transplantation

巻 31, 号 12, p. 2023-2033, 発行日 2016-12-09
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1093/ndt/gfw214
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26288
識別子タイプ HDL
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