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  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 79(2)

Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract

https://doi.org/10.18999/nagjms.79.2.167
https://doi.org/10.18999/nagjms.79.2.167
866621ec-dc69-49cf-bbea-1b9fe3bcdacb
名前 / ファイル ライセンス アクション
15_MilanBarai.pdf 15_MilanBarai.pdf (998.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-06-01
タイトル
タイトル Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract
言語 en
著者 Milan, Barai

× Milan, Barai

WEKO 71995

en Milan, Barai

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Nazmul, Ahsan

× Nazmul, Ahsan

WEKO 71996

en Nazmul, Ahsan

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Nilanjana, Paul

× Nilanjana, Paul

WEKO 71997

en Nilanjana, Paul

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Khaled, Hossain

× Khaled, Hossain

WEKO 71998

en Khaled, Hossain

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Mohammad, Abdur Rashid

× Mohammad, Abdur Rashid

WEKO 71999

en Mohammad, Abdur Rashid

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Kato, Masashi

× Kato, Masashi

WEKO 72000

en Kato, Masashi

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Ohgami, Nobutaka

× Ohgami, Nobutaka

WEKO 72001

en Ohgami, Nobutaka

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Anwarul, Azim Akhand

× Anwarul, Azim Akhand

WEKO 72002

en Anwarul, Azim Akhand

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報Resource http://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
キーワード
主題Scheme Other
主題 Sodium arsenite
キーワード
主題Scheme Other
主題 Mice
キーワード
主題Scheme Other
主題 S. cumini leaf extract
キーワード
主題Scheme Other
主題 Serum parameters
キーワード
主題Scheme Other
主題 Organ enlargement
抄録
内容記述タイプ Abstract
内容記述 Arsenic created a serious public health problem in Bangladesh due to its presence in groundwater and dissemination of the toxic effects to millions of people. The scarcity of the treatment options to manage this affected population has made the situation much worse. To find a promising treatment option, this study was undertaken to examine the ameliorating roles of Syzygium cumini leaf extract (SLE) against arsenicinduced toxic effects in mice. Swiss albino mice were divided into four groups where ‘control’ group received pure water + normal feed, ‘arsenic (As)’ group received sodium arsenite (NaAsO2)-containing water (10 μg/g body weight/day) + normal feed, ‘As+SLE’ group received NaAsO2-containing water + feed supplemented with SLE (50 μg/g body weight/day) and finally the ‘SLE’ group received pure water + feed supplemented with SLE. A gradual increase in body weight gain was observed in control mice; however, the body weight gain in As-exposed mice was decreased. This decrease in body weight gain was prevented in As+SLE group mice that received SLE supplemented feed. Arsenic showed a secondary effect by causing enlargement of spleen, kidney and liver of ‘As’ group mice and this enlargement of the organs was minimized with SLE supplementation. In addition, SLE abrogated arsenic-mediated elevation of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), uric acid and glucose. These results, therefore, suggest that SLE might have future therapeutic value for preventing or reducing arsenic-induced toxic effects.
言語 en
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.79.2.167
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/792.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 79, 号 2, p. 167-177, 発行日 2017-05
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/26539
識別子タイプ HDL
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