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Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract
https://doi.org/10.18999/nagjms.79.2.167
https://doi.org/10.18999/nagjms.79.2.167866621ec-dc69-49cf-bbea-1b9fe3bcdacb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
15_MilanBarai.pdf (998.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-06-01 | |||||
| タイトル | ||||||
| タイトル | Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract | |||||
| 言語 | en | |||||
| 著者 |
Milan, Barai
× Milan, Barai× Nazmul, Ahsan× Nilanjana, Paul× Khaled, Hossain× Mohammad, Abdur Rashid× Kato, Masashi× Ohgami, Nobutaka× Anwarul, Azim Akhand |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sodium arsenite | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | S. cumini leaf extract | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Serum parameters | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Organ enlargement | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Arsenic created a serious public health problem in Bangladesh due to its presence in groundwater and dissemination of the toxic effects to millions of people. The scarcity of the treatment options to manage this affected population has made the situation much worse. To find a promising treatment option, this study was undertaken to examine the ameliorating roles of Syzygium cumini leaf extract (SLE) against arsenicinduced toxic effects in mice. Swiss albino mice were divided into four groups where ‘control’ group received pure water + normal feed, ‘arsenic (As)’ group received sodium arsenite (NaAsO2)-containing water (10 μg/g body weight/day) + normal feed, ‘As+SLE’ group received NaAsO2-containing water + feed supplemented with SLE (50 μg/g body weight/day) and finally the ‘SLE’ group received pure water + feed supplemented with SLE. A gradual increase in body weight gain was observed in control mice; however, the body weight gain in As-exposed mice was decreased. This decrease in body weight gain was prevented in As+SLE group mice that received SLE supplemented feed. Arsenic showed a secondary effect by causing enlargement of spleen, kidney and liver of ‘As’ group mice and this enlargement of the organs was minimized with SLE supplementation. In addition, SLE abrogated arsenic-mediated elevation of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), uric acid and glucose. These results, therefore, suggest that SLE might have future therapeutic value for preventing or reducing arsenic-induced toxic effects. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.79.2.167 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/792.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 79, 号 2, p. 167-177, 発行日 2017-05 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26539 | |||||
| 識別子タイプ | HDL | |||||
