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Identification of a novel protein kinase that affects the chronological lifespan in fission yeast
http://hdl.handle.net/2237/26582
http://hdl.handle.net/2237/26582ffcbe680-71dc-4e88-ab09-bcdfc8ef0828
名前 / ファイル | ライセンス | アクション |
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Nnk1.pdf ファイル公開:2018/01/01 (8.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-06-07 | |||||
タイトル | ||||||
タイトル | Identification of a novel protein kinase that affects the chronological lifespan in fission yeast | |||||
言語 | en | |||||
著者 |
Kurauchi, Tatsuhiro
× Kurauchi, Tatsuhiro× Hashizume, Aya× Imai, Yuki× Hayashi, Kanako× Tsubouchi, Satoshi× Ihara, Kunio× Ohtsuka, Hokuto× Aiba, Hirofumi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in [FEMS Microbiology Letters] following peer review. The version of record [FEMS Microbiology Letters. v.364, n.2, 2017, p.fnw257] is available online at: https://doi.org/10.1093/femsle/fnw257 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lifespan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Schizosaccharomyces pombe | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glucose transporter | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nnk1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | yeast | |||||
抄録 | ||||||
内容記述 | Chronological lifespan is defined by how long a cell can survive in a non-dividing state. In yeast, it is measured by viability after entry into the stationary phase. To understand the regulatory mechanisms of chronological lifespan in Schizosaccharomyces pombe, it is necessary to identify and characterize novel factors involved in the regulation of chronological lifespan. To this end, we have screened for a long-lived mutant and identified that novel gene nnk1+ that encodes an essential protein kinase is the determinant of chronological lifespan. We showed that the expression of major glucose transporter gene, ght5+, is decreased in the isolated nnk1-35 mutant, suggesting that Nnk1 protein is involved in the regulation of ght5+. The consumption of glucose in the growth medium after saturated growth was lower in the nnk1-35 mutant than that in wild-type cell. The isolated ght5 deletion mutant showed long-lived phenotype. Based on these results, we propose that Nnk1 regulates chronological lifespan through the regulation of ght5+. Nnk1 might coordinate glucose availability and lifespan in fission yeast. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Oxford University Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/femsle/fnw257 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0378-1097 | |||||
書誌情報 |
en : FEMS Microbiology Letters 巻 364, 号 2, p. fnw257-fnw257, 発行日 2017-01 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | https://doi.org/10.1093/femsle/fnw257 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26582 | |||||
識別子タイプ | HDL |