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  1. D400 創薬科学研究科
  2. D400a 雑誌掲載論文
  3. 学術雑誌

Identification of a novel protein kinase that affects the chronological lifespan in fission yeast

http://hdl.handle.net/2237/26582
http://hdl.handle.net/2237/26582
ffcbe680-71dc-4e88-ab09-bcdfc8ef0828
名前 / ファイル ライセンス アクション
Nnk1.pdf Nnk1.pdf ファイル公開:2018/01/01 (8.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-06-07
タイトル
タイトル Identification of a novel protein kinase that affects the chronological lifespan in fission yeast
言語 en
著者 Kurauchi, Tatsuhiro

× Kurauchi, Tatsuhiro

WEKO 72176

en Kurauchi, Tatsuhiro

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Hashizume, Aya

× Hashizume, Aya

WEKO 72177

en Hashizume, Aya

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Imai, Yuki

× Imai, Yuki

WEKO 72178

en Imai, Yuki

Search repository
Hayashi, Kanako

× Hayashi, Kanako

WEKO 72179

en Hayashi, Kanako

Search repository
Tsubouchi, Satoshi

× Tsubouchi, Satoshi

WEKO 72180

en Tsubouchi, Satoshi

Search repository
Ihara, Kunio

× Ihara, Kunio

WEKO 72181

en Ihara, Kunio

Search repository
Ohtsuka, Hokuto

× Ohtsuka, Hokuto

WEKO 72182

en Ohtsuka, Hokuto

Search repository
Aiba, Hirofumi

× Aiba, Hirofumi

WEKO 72183

en Aiba, Hirofumi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [FEMS Microbiology Letters] following peer review. The version of record [FEMS Microbiology Letters. v.364, n.2, 2017, p.fnw257] is available online at: https://doi.org/10.1093/femsle/fnw257
キーワード
主題Scheme Other
主題 Lifespan
キーワード
主題Scheme Other
主題 Schizosaccharomyces pombe
キーワード
主題Scheme Other
主題 aging
キーワード
主題Scheme Other
主題 glucose transporter
キーワード
主題Scheme Other
主題 Nnk1
キーワード
主題Scheme Other
主題 yeast
抄録
内容記述 Chronological lifespan is defined by how long a cell can survive in a non-dividing state. In yeast, it is measured by viability after entry into the stationary phase. To understand the regulatory mechanisms of chronological lifespan in Schizosaccharomyces pombe, it is necessary to identify and characterize novel factors involved in the regulation of chronological lifespan. To this end, we have screened for a long-lived mutant and identified that novel gene nnk1+ that encodes an essential protein kinase is the determinant of chronological lifespan. We showed that the expression of major glucose transporter gene, ght5+, is decreased in the isolated nnk1-35 mutant, suggesting that Nnk1 protein is involved in the regulation of ght5+. The consumption of glucose in the growth medium after saturated growth was lower in the nnk1-35 mutant than that in wild-type cell. The isolated ght5 deletion mutant showed long-lived phenotype. Based on these results, we propose that Nnk1 regulates chronological lifespan through the regulation of ght5+. Nnk1 might coordinate glucose availability and lifespan in fission yeast.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/femsle/fnw257
ISSN
収録物識別子タイプ PISSN
収録物識別子 0378-1097
書誌情報 en : FEMS Microbiology Letters

巻 364, 号 2, p. fnw257-fnw257, 発行日 2017-01
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1093/femsle/fnw257
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26582
識別子タイプ HDL
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