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Epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer (Review)
http://hdl.handle.net/2237/26858
http://hdl.handle.net/2237/26858687d696c-dc0a-4a6f-9b57-f8fd3fb26e3c
名前 / ファイル | ライセンス | アクション |
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ol_13_5_3363_PDF.pdf ファイル公開:2017/11/01 (709.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-08-02 | |||||
タイトル | ||||||
タイトル | Epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer (Review) | |||||
言語 | en | |||||
著者 |
Sonohara, Fuminori
× Sonohara, Fuminori× Inokawa, Yoshikuni× Hayashi, Masamichi× Kodera, Yasuhiro× Nomoto, Shuji |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | Gastric cancer (GC) is a leading cause of cancer‑related death, particularly in Asia. Epidemiological and other clinical studies have identified an association between a number of risk factors, including Helicobacter pylori, and GC. A number of studies have also examined genetic changes associated with the development and progression of GC. When considering the clinical significance of the expression of a specific gene, its epigenetic modulation should be considered. Epigenetic modulation appears to be a primary driver of changes in gastric tissue that promotes carcinogenesis and progression of GC and other neoplasms. The role of epigenetic modulation in GC carcinogenesis and progression has been widely studied in recent years. In the present review, recent results of epigenetic modulation associated with GC and their effects on clinical outcome are examined, with particular respect to DNA methylation, histone modulation and non‑coding RNA. A number of studies indicate that epigenetic changes in the expression of specific genes critically affect their clinical significance and further study may reveal epigenetic changes as the basis for targeted molecular therapy or novel biomarkers that predict GC prognosis or extension of this often fatal disease. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Spandidos Publications | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3892/ol.2017.5912 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1792-1074 | |||||
書誌情報 |
en : Oncology Letters 巻 13, 号 5, p. 3363-3368, 発行日 2017-05 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | https://doi.org/10.3892/ol.2017.5912 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26858 | |||||
識別子タイプ | HDL |