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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma

http://hdl.handle.net/2237/26866
http://hdl.handle.net/2237/26866
7e5b2b61-6d6a-4cfd-a440-b6c7ce1a7682
名前 / ファイル ライセンス アクション
Spandidos_182960.pdf Spandidos_182960.pdf ファイル公開:2017/11/01 (2.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-02
タイトル
タイトル Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma
言語 en
著者 Asano, Tomonari

× Asano, Tomonari

WEKO 72994

en Asano, Tomonari

Search repository
Yamada, Suguru

× Yamada, Suguru

WEKO 72995

en Yamada, Suguru

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Fuchs, Bryan C.

× Fuchs, Bryan C.

WEKO 72996

en Fuchs, Bryan C.

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Takami, Hideki

× Takami, Hideki

WEKO 72997

en Takami, Hideki

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Hayashi, Masamichi

× Hayashi, Masamichi

WEKO 72998

en Hayashi, Masamichi

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Sugimoto, Hiroyuki

× Sugimoto, Hiroyuki

WEKO 72999

en Sugimoto, Hiroyuki

Search repository
Fujii, Tsutomu

× Fujii, Tsutomu

WEKO 73000

en Fujii, Tsutomu

Search repository
Tanabe, Kenneth K.

× Tanabe, Kenneth K.

WEKO 73001

en Tanabe, Kenneth K.

Search repository
Kodera, Yasuhiro

× Kodera, Yasuhiro

WEKO 73002

en Kodera, Yasuhiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 The epithelial-to-mesenchymal transition (EMT) is an initial, critical step in hepatocellular carcinoma (HCC) tumor invasion and metastasis. Frizzled 2 (Fzd2) expression might drive EMT through the non-canonical Wnt pathway, one of the various EMT signaling pathways. The expression of epithelial (E-cadherin) and mesenchymal (vimentin) markers, as well as that of Wnt5b, Stat3, IL-6, Jak2 and Fzd2, were measured in 15 HCC cell lines. The EMT status (vimentin to E-cadherin mRNA expression ratio), Fzd2 mRNA expression, and pSTAT3 protein expression were assessed by immunostaining in 100 HCC patients, and correlations of their expression with clinicopathological factors and prognosis were analyzed. Cell proliferation, migration, and invasiveness were assessed after Fzd2 knockdown. Fzd2 expression was significantly correlated with a mesenchymal phenotype in the HCC cell lines. Treatment of the cell lines with Fzd2 siRNA resulted in significantly reduced migration and invasiveness but did not affect proliferation. A significant correlation was detected between the EMT status and Fzd2 expression in the HCC patients. Multivariate analysis revealed that Fzd2 expression was an independent predictor of recurrence (P=0.034). Patients with high Fzd2 expression had significantly poorer recurrence‑free survival than those with low expression (P=0.03). Finally, pSTAT3 expression was significantly correlated with the EMT and Fzd2 status (P=0.0028, and P=0.0066, respectively). Fzd2 expression induced EMT and enhanced cell migration and invasiveness, and it might be a novel predictor of HCC recurrence. Furthermore, Stat3 might be controlled by both the Wnt5/Fzd2 and IL-6/Jak2 signaling pathways and play an important role in EMT.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Spandidos Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3892/ijo.2017.3937
ISSN
収録物識別子タイプ PISSN
収録物識別子 1019-6439
書誌情報 en : International Journal of Oncology

巻 50, 号 5, p. 1647-1654, 発行日 2017-05
著者版フラグ
値 author
URI
識別子 https://doi.org/10.3892/ijo.2017.3937
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26866
識別子タイプ HDL
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