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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Multiphoton microscopy observations of 3D elastin and collagen fiber microstructure changes during pressurization in aortic media

http://hdl.handle.net/2237/26876
ea079193-0e05-4fdd-9ec0-a80f2c20b85e
名前 / ファイル ライセンス アクション
SugitaBMMB17rep.pdf SugitaBMMB17rep.pdf ファイル公開:2018/06/01 (1.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-03
タイトル
タイトル Multiphoton microscopy observations of 3D elastin and collagen fiber microstructure changes during pressurization in aortic media
著者 Sugita, Shukei

× Sugita, Shukei

WEKO 73066

Sugita, Shukei

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Matsumoto, Takeo

× Matsumoto, Takeo

WEKO 73067

Matsumoto, Takeo

Search repository
権利
権利情報 The final publication is available at Springer via https://doi.org/10.1007/s10237-016-0851-9
キーワード
主題Scheme Other
主題 Thoracic aorta
キーワード
主題Scheme Other
主題 Waviness
キーワード
主題Scheme Other
主題 Second harmonic generation
キーワード
主題Scheme Other
主題 Two-photon microscopy
抄録
内容記述 Elastin and collagen fibers play important roles in the mechanical properties of aortic media. Because knowledge of local fiber structures is required for detailed analysis of blood vessel wall mechanics, we investigated 3D microstructures of elastin and collagen fibers in thoracic aortas and monitored changes during pressurization. Using multiphoton microscopy, autofluorescence images from elastin and second harmonic generation signals from collagen were acquired in media from rabbit thoracic aortas that were stretched biaxially to restore physiological dimensions. Both elastin and collagen fibers were observed in all longitudinal–circumferential plane images, whereas alternate bright and dark layers were observed along the radial direction and were recognized as elastic laminas (ELs) and smooth muscle-rich layers (SMLs), respectively. Elastin and collagen fibers are mainly oriented in the circumferential direction, and waviness of collagen fibers was significantly higher than that of elastin fibers. Collagen fibers were more undulated in longitudinal than in radial direction, whereas undulation of elastin fibers was equibiaxial. Changes in waviness of collagen fibers during pressurization were then evaluated using 2-dimensional fast Fourier transform in mouse aortas, and indices of waviness of collagen fibers decreased with increases in intraluminal pressure. These indices also showed that collagen fibers in SMLs became straight at lower intraluminal pressures than those in EL, indicating that SMLs stretched more than ELs. These results indicate that deformation of the aorta due to pressurization is complicated because of the heterogeneity of tissue layers and differences in elastic properties of ELs, SMLs, and surrounding collagen and elastin.
内容記述タイプ Abstract
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1617-7959
書誌情報 Biomechanics and Modeling in Mechanobiology

巻 16, 号 3, p. 763-773, 発行日 2017-06
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1007/s10237-016-0851-9
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26876
識別子タイプ HDL
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