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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy

http://hdl.handle.net/2237/26881
http://hdl.handle.net/2237/26881
c7ab462f-c89c-4438-84a9-805f9de51968
名前 / ファイル ライセンス アクション
Nakatsuji_H_J_Neurol_2017.pdf Nakatsuji_H_J_Neurol_2017.pdf ファイル公開:2018/05/01 (641.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-03
タイトル
タイトル Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy
言語 en
著者 Nakatsuji, Hideaki

× Nakatsuji, Hideaki

WEKO 73083

en Nakatsuji, Hideaki

Search repository
Araki, Amane

× Araki, Amane

WEKO 73084

en Araki, Amane

Search repository
Hashizume, Atsushi

× Hashizume, Atsushi

WEKO 73085

en Hashizume, Atsushi

Search repository
Hijikata, Yasuhiro

× Hijikata, Yasuhiro

WEKO 73086

en Hijikata, Yasuhiro

Search repository
Yamada, Shinichiro

× Yamada, Shinichiro

WEKO 73087

en Yamada, Shinichiro

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Inagaki, Tomonori

× Inagaki, Tomonori

WEKO 73088

en Inagaki, Tomonori

Search repository
Suzuki, Keisuke

× Suzuki, Keisuke

WEKO 73089

en Suzuki, Keisuke

Search repository
Banno, Haruhiko

× Banno, Haruhiko

WEKO 73090

en Banno, Haruhiko

Search repository
Suga, Noriaki

× Suga, Noriaki

WEKO 73091

en Suga, Noriaki

Search repository
Okada, Yohei

× Okada, Yohei

WEKO 73092

en Okada, Yohei

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Ohyama, Manabu

× Ohyama, Manabu

WEKO 73093

en Ohyama, Manabu

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Nakagawa, Tohru

× Nakagawa, Tohru

WEKO 73094

en Nakagawa, Tohru

Search repository
Kishida, Ken

× Kishida, Ken

WEKO 73095

en Kishida, Ken

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Funahashi, Tohru

× Funahashi, Tohru

WEKO 73096

en Funahashi, Tohru

Search repository
Shimomura, Iichiro

× Shimomura, Iichiro

WEKO 73097

en Shimomura, Iichiro

Search repository
Okano, Hideyuki

× Okano, Hideyuki

WEKO 73098

en Okano, Hideyuki

Search repository
Katsuno, Masahisa

× Katsuno, Masahisa

WEKO 73099

en Katsuno, Masahisa

Search repository
Sobue, Gen

× Sobue, Gen

WEKO 73100

en Sobue, Gen

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at Springer via https://doi.org/10.1007/s00415-017-8405-3
キーワード
主題Scheme Other
主題 Spinal and bulbar muscular atrophy
キーワード
主題Scheme Other
主題 SBMA
キーワード
主題Scheme Other
主題 Insulin resistance
キーワード
主題Scheme Other
主題 Insulin receptor
抄録
内容記述 This study aimed to evaluate various metabolic parameters in patients with spinal and bulbar muscular atrophy (SBMA), to investigate the association between those indices and disease severity, and to explore the underlying molecular pathogenesis. We compared the degree of obesity, metabolic parameters, and blood pressure in 55 genetically confirmed SBMA patients against those in 483 age- and sex-matched healthy control. In SBMA patients, we investigated the correlation between these factors and motor functional indices. SBMA patients had lower body mass index, blood glucose, and Hemoglobin A1c, but higher blood pressure, homeostasis model assessment of insulin resistance (HOMA-IR, a marker of insulin resistance), total cholesterol, and adiponectin levels than the control subjects. There were no differences in visceral fat areas, high-density lipoprotein-cholesterol (HDL-C), or triglyceride levels in two groups. Revised amyotrophic lateral sclerosis functional rating scale (ALSFRS-R) correlated positively with HDL-C, but negatively with HOMA-IR. Through stepwise multiple regression analysis, we identified HOMA-IR as a significant metabolic determinant of ALSFRS-R. In biochemical analysis, we found that decreased expressions of insulin receptors, insulin receptor substrate-1 and insulin receptor-β, in autopsied muscles and fibroblasts of SBMA patients. This study demonstrates that SBMA patients have insulin resistance, which is associated with the disease severity. The expressions of insulin receptors are attenuated in the skeletal muscle of SBMA, providing a possible pathomechanism of metabolic alterations. These findings suggested that insulin resistance is a metabolic index reflecting disease severity and pathogenesis as well as a potential therapeutic target for SBMA.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00415-017-8405-3
ISSN
収録物識別子タイプ PISSN
収録物識別子 0340-5354
書誌情報 en : Journal of Neurology

巻 264, 号 5, p. 839-847, 発行日 2017-05
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s00415-017-8405-3
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26881
識別子タイプ HDL
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