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Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis
http://hdl.handle.net/2237/26968
http://hdl.handle.net/2237/26968f4acf830-e3d6-4ac7-ba09-24f9a260ca8e
名前 / ファイル | ライセンス | アクション |
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Toyokuni_FRBM_Fe_Review_Repository.pdf ファイル公開:2018/07/01 (2.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-06 | |||||
タイトル | ||||||
タイトル | Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis | |||||
言語 | en | |||||
著者 |
Toyokuni, Shinya
× Toyokuni, Shinya× Ito, Fumiya× Yamashita, Kyoko× Okazaki, Yasumasa× Akatsuka, Shinya |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
抄録 | ||||||
内容記述 | Epidemiological data indicate a constant worldwide increase in cancer mortality, although the age of onset is increasing. Recent accumulation of genomic data on human cancer via next-generation sequencing confirmed that cancer is a disease of genome alteration. In many cancers, the Nrf2 transcription system is activated via mutations either in Nrf2 or Keap1 ubiquitin ligase, leading to persistent activation of the genes with antioxidative functions. Furthermore, deep sequencing of passenger mutations is clarifying responsible cancer causative agent(s) in each case, including aging, APOBEC activation, smoking and UV. Therefore, it is most likely that oxidative stress is the principal initiating factor in carcinogenesis, with the involvement of two essential molecules for life, iron and oxygen. There is evidence based on epidemiological and animal studies that excess iron is a major risk for carcinogenesis, suggesting the importance of ferroptosis-resistance. Microscopic visualization of catalytic Fe(II) has recently become available. Although catalytic Fe(II) is largely present in lysosomes, proliferating cells harbor catalytic Fe(II) also in the cytosol and mitochondria. Oxidative stress catalyzed by Fe(II) is counteracted by thiol systems at different functional levels. Nitric oxide, carbon monoxide and hydrogen (per)sulfide modulate these reactions. Mitochondria generate not only energy but also heme/iron sulfur cluster cofactors and remain mostly dysfunctional in cancer cells, leading to Warburg effects. Cancer cells are under persistent oxidative stress with a delicate balance between catalytic iron and thiols, thereby escaping ferroptosis. Thus, high-dose L-ascorbate and non-thermal plasma as well as glucose/glutamine deprivation may provide additional benefits as cancer therapies over preexisting therapeutics. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
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言語 | en | |||||
出版者 | Elsevier | |||||
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言語 | eng | |||||
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資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
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出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.freeradbiomed.2017.04.024 | |||||
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収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0891-5849 | |||||
書誌情報 |
en : Free Radical Biology and Medicine 巻 108, p. 610-626, 発行日 2017-07 |
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値 | author | |||||
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識別子 | https://doi.org/10.1016/j.freeradbiomed.2017.04.024 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26968 | |||||
識別子タイプ | HDL |