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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Overexpression of Derlin 3 is associated with malignant phenotype of breast cancer cells

http://hdl.handle.net/2237/27066
http://hdl.handle.net/2237/27066
984b3566-7f90-4b7a-b328-2bad19d02f5b
名前 / ファイル ライセンス アクション
DERL3-BCC_Oncol_Rep_2017.pdf DERL3-BCC_Oncol_Rep_2017.pdf ファイル公開日:2018/01/10 (555.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-11-07
タイトル
タイトル Overexpression of Derlin 3 is associated with malignant phenotype of breast cancer cells
言語 en
著者 Masahiro, Shibata

× Masahiro, Shibata

WEKO 73868

en Masahiro, Shibata

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Mitsuro, Kanda

× Mitsuro, Kanda

WEKO 73869

en Mitsuro, Kanda

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Haruyoshi, Tanaka

× Haruyoshi, Tanaka

WEKO 73870

en Haruyoshi, Tanaka

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Shinichi, Umeda

× Shinichi, Umeda

WEKO 73871

en Shinichi, Umeda

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Takashi, Miwa

× Takashi, Miwa

WEKO 73872

en Takashi, Miwa

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Dai, Shimizu

× Dai, Shimizu

WEKO 73873

en Dai, Shimizu

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Masamichi, Hayashi

× Masamichi, Hayashi

WEKO 73874

en Masamichi, Hayashi

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Takahiro, Inaishi

× Takahiro, Inaishi

WEKO 73875

en Takahiro, Inaishi

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Noriyuki, Miyajima

× Noriyuki, Miyajima

WEKO 73876

en Noriyuki, Miyajima

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Yayoi, Adachi

× Yayoi, Adachi

WEKO 73877

en Yayoi, Adachi

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Yuko, Takano

× Yuko, Takano

WEKO 73878

en Yuko, Takano

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Kenichi, Nakanishi

× Kenichi, Nakanishi

WEKO 73879

en Kenichi, Nakanishi

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Dai, Takeuchi

× Dai, Takeuchi

WEKO 73880

en Dai, Takeuchi

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Sumiyo, Noda

× Sumiyo, Noda

WEKO 73881

en Sumiyo, Noda

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Yasuhiro, Kodera

× Yasuhiro, Kodera

WEKO 73882

en Yasuhiro, Kodera

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Toyone, Kikumori

× Toyone, Kikumori

WEKO 73883

en Toyone, Kikumori

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
抄録
内容記述 Breast cancer (BC) is the most common malignant tumor among women worldwide. Development of novel molecular targets is important to improve prognosis of BC patients. Derlin 3 (DERL3) gene is a member of derlin family, and its coding protein is critical to the endoplasmic reticulum-associated degradation mechanism. However, its oncological role in breast cancer remains unclear. This study evaluated DERL3 expression and function in BC. We analyzed DERL3 mRNA in 13 BC and two non-cancerous cell lines, and explored effects of DERL3 knockdown on BC proliferation, invasion and migration. We also evaluated correlation of DERL3 mRNA expression levels with clinicopathological factors and prognosis in 167 BC patients. DERL3 mRNA expression was detected in five (38%) BC cell lines. Inhibiting DERL3 expression significantly decreased proliferation and invasion in BC cells. Specimens from patients with lymph node metastasis had higher DERL3 mRNA expression than those without (P=0.030). Patients in the highest quartile for DERL3 mRNA expression (n=42) were more likely to experience shorter overall survival than other patients (P=0.032). These findings indicate that DERL3 promotes malignant phenotype in BC cells. DERL3 may serve as a potential prognostic marker and therapeutic target for BC.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Spandidos Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3892/or.2017.5800
ISSN
収録物識別子タイプ PISSN
収録物識別子 1021-335X
書誌情報 en : Oncology Reports

巻 38, 号 3, p. 1760-1766, 発行日 2017-07-10
著者版フラグ
値 author
URI
識別子 http://doi.org/10.3892/or.2017.5800
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27066
識別子タイプ HDL
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