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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

http://hdl.handle.net/2237/27092
d4ae0605-8aa8-4b39-aad3-075032ebee41
名前 / ファイル ライセンス アクション
kondo.pdf kondo.pdf ファイル公開日:2018/02/10 (2.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-11-13
タイトル
タイトル Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis
著者 Deguchi, S

× Deguchi, S

WEKO 74001

Deguchi, S

Search repository
Katsushima, K

× Katsushima, K

WEKO 74002

Katsushima, K

Search repository
Hatanaka, A

× Hatanaka, A

WEKO 74003

Hatanaka, A

Search repository
Shinjo, K

× Shinjo, K

WEKO 74004

Shinjo, K

Search repository
Ohka, F

× Ohka, F

WEKO 74005

Ohka, F

Search repository
Wakabayashi, T

× Wakabayashi, T

WEKO 74006

Wakabayashi, T

Search repository
Zong, H

× Zong, H

WEKO 74007

Zong, H

Search repository
Natsume, A

× Natsume, A

WEKO 74008

Natsume, A

Search repository
Kondo, Y

× Kondo, Y

WEKO 74009

Kondo, Y

Search repository
キーワード
主題Scheme Other
主題 long non-coding RNA
キーワード
主題Scheme Other
主題 conservation
キーワード
主題Scheme Other
主題 glioma
抄録
内容記述 Accumulating studies have demonstrated the importance of long noncoding RNAs (lncRNAs) during oncogenic transformation. However, because most lncRNAs are currently uncharacterized, the identification of novel oncogenic lncRNAs is difficult. Given that intergenic lncRNA have substantially less sequence conservation patterns than protein-coding genes across species, evolutionary conserved intergenic lncRNAs are likely to be functional. The current study identified a novel intergenic lncRNA, LINC00461 (ECONEXIN) using a combined approach consisting of searching lncRNAs by evolutionary conservation and validating their expression in a glioma mouse model. ECONEXIN was the most highly conserved intergenic lncRNA containing 83.0% homology with the mouse ortholog (C130071C03Rik) for a region over 2500 bp in length within its exon 3. Expressions of ECONEXIN and C130071C03Rik were significantly upregulated in both human and mouse glioma tissues. Moreover, the expression of C130071C03Rik was upregulated even in precancerous conditions and markedly increased during glioma progression. Functional analysis of ECONEXIN in glioma cell lines, U87 and U251, showed it was dominantly located in the cytoplasm and interacted with miR-411-5p via two binding sites within ECONEXIN. Inhibition of ECONEXIN upregulated miR-411-5p together with the downregulation of its target, Topoisomerase 2 alpha (TOP2A), in glioma cell lines, resulting in decreased cell proliferation. Our data demonstrated that ECONEXIN is a potential oncogene that regulates TOP2A by sponging miR-411-5p in glioma. In addition, our investigative approaches to identify conserved lncRNA and their molecular characterization by validation in mouse tumor models may be useful to functionally annotate novel lncRNAs, especially cancer-associated lncRNAs.
内容記述タイプ Abstract
出版者
出版者 nature
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0950-9232
書誌情報 Oncogene

巻 36, 号 32, p. 4629-4640, 発行日 2017-08-10
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1038/onc.2017.88
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27092
識別子タイプ HDL
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