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  1. H180 生物機能開発利用研究センター
  2. H180a 雑誌掲載論文
  3. 学術雑誌

Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination

http://hdl.handle.net/2237/27156
http://hdl.handle.net/2237/27156
7e4b9a81-9abe-4bdc-afe5-afbd4706c86e
名前 / ファイル ライセンス アクション
Movies_S3.mov Movies_S3.mov ファイル公開:2018/08/01 (5.5 MB)
Movies_S2.mov Movies_S2.mov ファイル公開:2018/08/01 (4.8 MB)
Movies_S1.mov Movies_S1.mov ファイル公開:2018/08/01 (4.7 MB)
Takeuchi_Genes_Cells_2017.pdf Takeuchi_Genes_Cells_2017.pdf ファイル公開:2018/08/01 (26.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-12-08
タイトル
タイトル Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination
言語 en
著者 Takeuchi, Miki

× Takeuchi, Miki

WEKO 74306

en Takeuchi, Miki

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Inoue, Chikako

× Inoue, Chikako

WEKO 74307

en Inoue, Chikako

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Goshima, Akiko

× Goshima, Akiko

WEKO 74308

en Goshima, Akiko

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Nagao, Yusuke

× Nagao, Yusuke

WEKO 74309

en Nagao, Yusuke

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Shimizu, Koichi

× Shimizu, Koichi

WEKO 74310

en Shimizu, Koichi

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Miyamoto, Hiroki

× Miyamoto, Hiroki

WEKO 74311

en Miyamoto, Hiroki

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Shimizu, Takashi

× Shimizu, Takashi

WEKO 74312

en Shimizu, Takashi

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Hashimoto, Hisashi

× Hashimoto, Hisashi

WEKO 74313

en Hashimoto, Hisashi

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Yonemura, Shigenobu

× Yonemura, Shigenobu

WEKO 74314

en Yonemura, Shigenobu

Search repository
Kawahara, Atsuo

× Kawahara, Atsuo

WEKO 74315

en Kawahara, Atsuo

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Hirata, Yutaka

× Hirata, Yutaka

WEKO 74316

en Hirata, Yutaka

Search repository
Yoshida, Masayuki

× Yoshida, Masayuki

WEKO 74317

en Yoshida, Masayuki

Search repository
Hibi, Masahiko

× Hibi, Masahiko

WEKO 74318

en Hibi, Masahiko

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Takeuchi, M., Inoue, C., Goshima, A., Nagao, Y., Shimizu, K., Miyamoto, H., Shimizu, T., Hashimoto, H., Yonemura, S., Kawahara, A., Hirata, Y., Yoshida, M. and Hibi, M. (2017), Medaka and zebrafish contactin1 mutants as a model for understanding neural circuits for motor coordination. Genes Cells, 22: 723–741. doi:10.1111/gtc.12509], which has been published in final form at [http://doi.org/10.1111/gtc.12509]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 A spontaneous medaka ro mutant shows abnormal wobbling and rolling swimming behaviors. By positional cloning, we mapped the ro locus to a region containing the gene encoding Contactin1b (Cntn1b), which is an immunoglobulin (Ig)-superfamily domain-containing membrane-anchored protein. The ro mutant had a deletion in the cntn1b gene that introduced a premature stop codon. Furthermore, cntn1b mutants generated by the CRISPR/Cas9 system and trans-heterozygotes of the CRISPR mutant allele and ro had abnormal swimming behavior, indicating that the cntn1b gene was responsible for the ro-mutant phenotype. We also established zebrafish cntn1a and cntn1b mutants by transcription activator-like effector nucleases (TALENs). Zebrafish cntn1b but not cntn1a mutants showed abnormal swimming behaviors similar to those in the ro mutant, suggesting that Cntn1b plays a conserved role in the formation or function of the neural circuits that control swimming in teleosts. Although Cntn1-deficient mice have abnormal cerebellar neural circuitry, there was no apparent histological abnormality in the cerebellum of medaka or zebrafish cntn1b mutants. The medaka cntn1b mutants had defective optokinetic response (OKR) adaptation and abnormal rheotaxis (body positioning relative to water flow). Medaka and zebrafish cntn1b mutants are effective models for studying the neural circuits involved in motor learning and motor coordination.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/gtc.12509
ISSN
収録物識別子タイプ PISSN
収録物識別子 1356-9597
書誌情報 en : GENES TO CELLS

巻 22, 号 8, p. 723-741, 発行日 2017-08
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1111/gtc.12509
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27156
識別子タイプ HDL
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