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Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability
http://hdl.handle.net/2237/27159
http://hdl.handle.net/2237/271592e87b4cf-eae5-4980-b51b-805e8880b8c2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Fukuda_HumMolGenet_2017.pdf ファイル公開：2018/09/15 (2.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-12-08 | |||||
| タイトル | ||||||
| タイトル | Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability | |||||
| 言語 | en | |||||
| 著者 |
Fukuda, Kei
× Fukuda, Kei× Inoguchi, Yukihiro× Ichiyanagi, Kenji× Ichiyanagi, Tomoko× Go, Yasuhiro× Nagano, Masashi× Yanagawa, Yojiro× Takaesu, Noboru× Ohkawa, Yasuyuki× Imai, Hiroo× Sasaki, Hiroyuki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in [Human Molecular Genetics] following peer review. The version of record [Human Molecular Genetics. v.26, n.18, 2017, p.3508-3519] is available online at: https://doi.org/10.1093/hmg/ddx236. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | genome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | methylation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxymetholone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pan troglodytes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | primates | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sperm cell | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Changes in gene expression resulting from epigenetic and/or genetic changes play an important role in the evolutionary divergence of phenotypes. To explore how epigenetic and genetic changes are linked during primate evolution, we have compared the genome-wide DNA methylation profiles (methylomes) of humans and chimpanzees, which have a 1.2% DNA sequence divergence, of sperm, the frontal cortices, B cells, and neutrophils. We revealed that species-specific differentially methylated regions (S-DMRs), ranging from several hundred base pairs (bp) to several kilo base pairs (kb), were frequently associated with sequence changes in transcription factor-binding sites and insertions of Alu and SVA retrotransposons. We then generated a reference macaque sperm methylome map and revealed, in sperm, that both human and chimpanzee S-DMRs arose more frequently owing to methylation loss rather than gain. Moreover, we observed that the sperm methylomes contained many more hypomethylated domains (HMDs), ranging from 20 to 500 kb, than did the somatic methylomes. Interestingly, the sperm HMDs changed rapidly during primate evolution; hundreds of sperm HMDs were specific to humans, whereas most somatic HMDs were highly conserved between humans and chimpanzees. Notably, these human-specific sperm HMDs frequently occurred in regions exhibiting copy number variations. Our findings indicate that primate evolution, particularly in the germline, is significantly impacted by reciprocal changes in the genome and epigenome. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/hmg/ddx236 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0964-6906 | |||||
| 書誌情報 |
en : Human Molecular Genetics 巻 26, 号 18, p. 3508-3519, 発行日 2017-09-15 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | https://doi.org/10.1093/hmg/ddx236 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27159 | |||||
| 識別子タイプ | HDL | |||||
