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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability

http://hdl.handle.net/2237/27159
http://hdl.handle.net/2237/27159
2e87b4cf-eae5-4980-b51b-805e8880b8c2
名前 / ファイル ライセンス アクション
Fukuda_HumMolGenet_2017.pdf Fukuda_HumMolGenet_2017.pdf ファイル公開:2018/09/15 (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-12-08
タイトル
タイトル Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability
言語 en
著者 Fukuda, Kei

× Fukuda, Kei

WEKO 74324

en Fukuda, Kei

Search repository
Inoguchi, Yukihiro

× Inoguchi, Yukihiro

WEKO 74325

en Inoguchi, Yukihiro

Search repository
Ichiyanagi, Kenji

× Ichiyanagi, Kenji

WEKO 74326

en Ichiyanagi, Kenji

Search repository
Ichiyanagi, Tomoko

× Ichiyanagi, Tomoko

WEKO 74327

en Ichiyanagi, Tomoko

Search repository
Go, Yasuhiro

× Go, Yasuhiro

WEKO 74328

en Go, Yasuhiro

Search repository
Nagano, Masashi

× Nagano, Masashi

WEKO 74329

en Nagano, Masashi

Search repository
Yanagawa, Yojiro

× Yanagawa, Yojiro

WEKO 74330

en Yanagawa, Yojiro

Search repository
Takaesu, Noboru

× Takaesu, Noboru

WEKO 74331

en Takaesu, Noboru

Search repository
Ohkawa, Yasuyuki

× Ohkawa, Yasuyuki

WEKO 74332

en Ohkawa, Yasuyuki

Search repository
Imai, Hiroo

× Imai, Hiroo

WEKO 74333

en Imai, Hiroo

Search repository
Sasaki, Hiroyuki

× Sasaki, Hiroyuki

WEKO 74334

en Sasaki, Hiroyuki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Human Molecular Genetics] following peer review. The version of record [Human Molecular Genetics. v.26, n.18, 2017, p.3508-3519] is available online at: https://doi.org/10.1093/hmg/ddx236.
キーワード
主題Scheme Other
主題 genome
キーワード
主題Scheme Other
主題 methylation
キーワード
主題Scheme Other
主題 oxymetholone
キーワード
主題Scheme Other
主題 pan troglodytes
キーワード
主題Scheme Other
主題 primates
キーワード
主題Scheme Other
主題 sperm cell
抄録
内容記述 Changes in gene expression resulting from epigenetic and/or genetic changes play an important role in the evolutionary divergence of phenotypes. To explore how epigenetic and genetic changes are linked during primate evolution, we have compared the genome-wide DNA methylation profiles (methylomes) of humans and chimpanzees, which have a 1.2% DNA sequence divergence, of sperm, the frontal cortices, B cells, and neutrophils. We revealed that species-specific differentially methylated regions (S-DMRs), ranging from several hundred base pairs (bp) to several kilo base pairs (kb), were frequently associated with sequence changes in transcription factor-binding sites and insertions of Alu and SVA retrotransposons. We then generated a reference macaque sperm methylome map and revealed, in sperm, that both human and chimpanzee S-DMRs arose more frequently owing to methylation loss rather than gain. Moreover, we observed that the sperm methylomes contained many more hypomethylated domains (HMDs), ranging from 20 to 500 kb, than did the somatic methylomes. Interestingly, the sperm HMDs changed rapidly during primate evolution; hundreds of sperm HMDs were specific to humans, whereas most somatic HMDs were highly conserved between humans and chimpanzees. Notably, these human-specific sperm HMDs frequently occurred in regions exhibiting copy number variations. Our findings indicate that primate evolution, particularly in the germline, is significantly impacted by reciprocal changes in the genome and epigenome.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/hmg/ddx236
ISSN
収録物識別子タイプ PISSN
収録物識別子 0964-6906
書誌情報 en : Human Molecular Genetics

巻 26, 号 18, p. 3508-3519, 発行日 2017-09-15
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1093/hmg/ddx236
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27159
識別子タイプ HDL
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