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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Rapid Worsening of Symptoms and High Cell Proliferative Activity in Intra- and Extramedullary Spinal Hemangioblastoma : A Need for Earlier Surgery

http://hdl.handle.net/2237/27176
http://hdl.handle.net/2237/27176
66ea39df-611c-4d0b-8e8c-8682cb9a18ac
名前 / ファイル ライセンス アクション
10_1055_s-0036-1580612.pdf 10_1055_s-0036-1580612.pdf (313.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-12-20
タイトル
タイトル Rapid Worsening of Symptoms and High Cell Proliferative Activity in Intra- and Extramedullary Spinal Hemangioblastoma : A Need for Earlier Surgery
言語 en
著者 Imagama, Shiro

× Imagama, Shiro

WEKO 74409

en Imagama, Shiro

Search repository
Ito, Zenya

× Ito, Zenya

WEKO 74410

en Ito, Zenya

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Ando, Kei

× Ando, Kei

WEKO 74411

en Ando, Kei

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Kobayashi, Kazuyoshi

× Kobayashi, Kazuyoshi

WEKO 74412

en Kobayashi, Kazuyoshi

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Hida, Tetsuro

× Hida, Tetsuro

WEKO 74413

en Hida, Tetsuro

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Ito, Kenyu

× Ito, Kenyu

WEKO 74414

en Ito, Kenyu

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Ishikawa, Yoshimoto

× Ishikawa, Yoshimoto

WEKO 74415

en Ishikawa, Yoshimoto

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Tsushima, Mikito

× Tsushima, Mikito

WEKO 74416

en Tsushima, Mikito

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Matsumoto, Akiyuki

× Matsumoto, Akiyuki

WEKO 74417

en Matsumoto, Akiyuki

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Nakashima, Hiroaki

× Nakashima, Hiroaki

WEKO 74418

en Nakashima, Hiroaki

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Wakao, Norimitsu

× Wakao, Norimitsu

WEKO 74419

en Wakao, Norimitsu

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Sakai, Yoshihito

× Sakai, Yoshihito

WEKO 74420

en Sakai, Yoshihito

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Matsuyama, Yukihiro

× Matsuyama, Yukihiro

WEKO 74421

en Matsuyama, Yukihiro

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Ishiguro, Naoki

× Ishiguro, Naoki

WEKO 74422

en Ishiguro, Naoki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (http://www.creativecommons.org/licenses/by-nc-nd/3.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
抄録
内容記述 Study Design: A retrospective analysis of a prospective database. Objective: To compare preoperative symptoms, ambulatory ability, intraoperative spinal cord monitoring, and pathologic cell proliferation activity between intramedullary only and intramedullary plus extramedullary hemangioblastomas, with the goal of determining the optimal timing for surgery. Methods: The subjects were 28 patients (intramedullary only in 23 cases [group I] and intramedullary plus extramedullary in 5 cases [group IE]) who underwent surgery for spinal hemangioblastoma. Preoperative symptoms, ambulatory ability on the McCormick scale, intraoperative spinal cord monitoring, and pathologic findings using Ki67 were compared between the groups. Results: In group IE, preoperative motor paralysis was significantly higher (100 versus 26%, p < 0.005), the mean period from initial symptoms to motor paralysis was significantly shorter (3.5 versus 11.9 months, p < 0.05), and intraoperative spinal cord monitoring aggravation was higher (65 versus 6%, p < 0.05). All 5 patients without total resection in group I underwent reoperation. Ki67 activity was higher in group IE (15% versus 1%, p < 0.05). Preoperative ambulatory ability was significantly poorer in group IE (p < 0.05), but all cases in this group improved after surgery, and postoperative ambulatory ability did not differ significantly between the two groups. Conclusions: Intramedullary plus extramedullary spinal hemangioblastoma is characterized by rapid preoperative progression of symptoms over a short period, severe spinal cord damage including preoperative motor paralysis, and poor gait ability compared with an intramedullary tumor only. Earlier surgery with intraoperative spinal cord monitoring is recommended for total resection and good surgical outcome especially for an IE tumor compared with an intramedullary tumor.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 SAGE Publications
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1055/s-0036-1580612
ISSN
収録物識別子タイプ PISSN
収録物識別子 2192-5682
書誌情報 en : Global Spine Journal

巻 7, 号 1, p. 6-13, 発行日 2017-04
著者版フラグ
値 publisher
URI
識別子 https://doi.org/10.1055/s-0036-1580612
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27176
識別子タイプ HDL
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