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Rapid Worsening of Symptoms and High Cell Proliferative Activity in Intra- and Extramedullary Spinal Hemangioblastoma : A Need for Earlier Surgery
http://hdl.handle.net/2237/27176
http://hdl.handle.net/2237/2717666ea39df-611c-4d0b-8e8c-8682cb9a18ac
| 名前 / ファイル | ライセンス | アクション |
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10_1055_s-0036-1580612.pdf (313.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-12-20 | |||||
| タイトル | ||||||
| タイトル | Rapid Worsening of Symptoms and High Cell Proliferative Activity in Intra- and Extramedullary Spinal Hemangioblastoma : A Need for Earlier Surgery | |||||
| 言語 | en | |||||
| 著者 |
Imagama, Shiro
× Imagama, Shiro× Ito, Zenya× Ando, Kei× Kobayashi, Kazuyoshi× Hida, Tetsuro× Ito, Kenyu× Ishikawa, Yoshimoto× Tsushima, Mikito× Matsumoto, Akiyuki× Nakashima, Hiroaki× Wakao, Norimitsu× Sakai, Yoshihito× Matsuyama, Yukihiro× Ishiguro, Naoki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License (http://www.creativecommons.org/licenses/by-nc-nd/3.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). | |||||
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| 内容記述タイプ | Abstract | |||||
| 内容記述 | Study Design: A retrospective analysis of a prospective database. Objective: To compare preoperative symptoms, ambulatory ability, intraoperative spinal cord monitoring, and pathologic cell proliferation activity between intramedullary only and intramedullary plus extramedullary hemangioblastomas, with the goal of determining the optimal timing for surgery. Methods: The subjects were 28 patients (intramedullary only in 23 cases [group I] and intramedullary plus extramedullary in 5 cases [group IE]) who underwent surgery for spinal hemangioblastoma. Preoperative symptoms, ambulatory ability on the McCormick scale, intraoperative spinal cord monitoring, and pathologic findings using Ki67 were compared between the groups. Results: In group IE, preoperative motor paralysis was significantly higher (100 versus 26%, p < 0.005), the mean period from initial symptoms to motor paralysis was significantly shorter (3.5 versus 11.9 months, p < 0.05), and intraoperative spinal cord monitoring aggravation was higher (65 versus 6%, p < 0.05). All 5 patients without total resection in group I underwent reoperation. Ki67 activity was higher in group IE (15% versus 1%, p < 0.05). Preoperative ambulatory ability was significantly poorer in group IE (p < 0.05), but all cases in this group improved after surgery, and postoperative ambulatory ability did not differ significantly between the two groups. Conclusions: Intramedullary plus extramedullary spinal hemangioblastoma is characterized by rapid preoperative progression of symptoms over a short period, severe spinal cord damage including preoperative motor paralysis, and poor gait ability compared with an intramedullary tumor only. Earlier surgery with intraoperative spinal cord monitoring is recommended for total resection and good surgical outcome especially for an IE tumor compared with an intramedullary tumor. | |||||
| 言語 | en | |||||
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| 出版者 | SAGE Publications | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1055/s-0036-1580612 | |||||
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| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 2192-5682 | |||||
| 書誌情報 |
en : Global Spine Journal 巻 7, 号 1, p. 6-13, 発行日 2017-04 |
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| 値 | publisher | |||||
| URI | ||||||
| 識別子 | https://doi.org/10.1055/s-0036-1580612 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27176 | |||||
| 識別子タイプ | HDL | |||||
